Janes T, Cardani S, Pagliardini S (2024) The progestinic drug, etonogestrel, rescues breathing in a rodent model of central chemoreflex impairment. Am Physiol Summit 39(S1) doi: 10.1152/physiol.2024.39.S1.978
Objective: Assessing the efficacy of etonogestrel as a treatment to congenital hypoventilation syndrome (CCHS).
Summary: Etonogestrel can stimulate breathing and CO2-chemoreflexes and could be used to treat congenital hypoventilation syndrome. A model of CCHS was created in rats through the ablation of retrotrapezoid nucleus neurons with substance-P saporin. In this CCHS model-rat Etonogestrel was assessed for its ability to return breathing back to normal and for its mechanism of action.
Usage: Rats were lesioned with SSP-SAP [IT-11] targeting the retrotrapezoid nucelus (R.V.N.) neurons.
Related Products: SSP-SAP (Cat. #IT-11)