Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications

Kniffin A, Bangasser DA, Parikh V (2024) Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications. Eur J Neurosci 59(9):2155-2180. doi: 10.1111/ejn.15999 PMID: 37118907

Objective: Review current research highlighting the contributions of cholinergic septohippocampal pathway (SHP) in modulating memory encoding, consolidation, and retrieval.

Summary: Authors presented evidence generated from empirical research and computational modeling approaches that suggest cholinergic SHP modulate distinct components of episodic memory. Specifically, higher levels of septohippocampal ACh and downstream activation of specific subtypes of mAChRs/nAChRs in local circuits of hippocampal networks reduce interference and enhance encoding, while lower cholinergic signaling facilitate memory consolidation by gating information to the neocortex.

Usage: Rats with cholinergic deficit in the SHP pathway were induced by injection with 192-IgG-SAP (IT-01).

Related Products: 192-IgG-SAP (Cat. #IT-01)

See Also:

• Baxter MG et al. Intact spatial learning following lesions of basal forebrain cholinergic neurons. NeuroReport 7:1417-1420, 1996.
• Baxter MG et al. Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input. Behav Neurosci 110:460-467, 1996.
• Bizon JL et al. Effects of hippocampal cholinergic deafferentation on learning strategy selection in a visible platform version of the water maze. Hippocampus 13(6):676-684, 2003.
• Frick KM et al. Effects of complete immunotoxin lesions of the cholinergic basal forebrain on fear conditioning and spatial learning. Hippocampus 14:244-254, 2004.