Frick KM, Jeansok JK, Baxter MG (2004) Effects of complete immunotoxin lesions of the cholinergic basal forebrain on fear conditioning and spatial learning. Hippocampus 14:244-254. doi: 10.1002/hipo.10169
Summary: The authors examined the hypothesis that basal forebrain cholinergic neurons are critical for acquisition and consolidation of fear conditioning by lesioning the medial septum/vertical limb of the diagonal band, the horizontal limb of the diagonal band of Broca, and the nucleus basalis magnocellularis of rats with 192-Saporin (Cat. #IT-01). The lesions did not impair contextual fear conditioning, implying that impairments induced by scopolamine may not be mediated by cholinergic input to the hippocampus and neocortex.
Related Products: 192-IgG-SAP (Cat. #IT-01)