Nirogi R, Jayarajan P, Benade V, Abraham R, Goyal VK (2024) Hits and misses with animal models of narcolepsy and the implications for drug discovery. Expert Opin Drug Discov 19(6):755-768. doi: 10.1080/17460441.2024.2354293 PMID: 38747534
Objective: To review the usage of Orexin-B-SAP treated rats in the development of drug candidates for the treatment of narcolepsy.
Summary: Examines pharmacological agents used for the modeling of narcolepsy in animals and contrasts it with narcolepsy expression in real patients. Additionally summarizes the discovery of the orexin system in narcolepsy and how animal models aided in that discovery.
Usage: Orexin- B-saporin (IT-20) was injected into the lateral hypothalamus of rats.
Related Products: Orexin-B-SAP (Cat. #IT-20)