Orexin-B-SAP [IT-20, KIT-20]

a tool for eliminating cells that express the orexin-2 receptor; targeted via orexin-B peptide, eliminated via saporin

SKU: IT-20 Category: Quantity: Individual 25 ug, Individual 100 ug, Individual 250 ug, Individual 1 mg, Kit w/controls 25 ug, Kit w/controls 100 ug, Kit w/controls 250 ug | Conjugate: saporin | Usage: eliminates cells |

The orexin A and orexin B receptors (also known as hypocretin 1 and 2) are found in the perifornical area/latero-posterior hypothalamus, and projections from this area cover much of the brain. These receptors have been implicated in various neurophysiological and neuropsychological disorders such as narcolepsy, insomnia, drug addiction, anxiety, and migraine headaches. The orexin-B-SAP conjugate consists of the rat/mouse orexin-B peptide conjugated to saporin. Orexin-B binds to the hypocretin (HCRT)-2 receptor with approximately 5-times greater affinity than to the HCRT-1 receptor.

Orexin-B-SAP is a chemical conjugate between orexin-B and the ribosome-inactivating protein, saporin. It eliminates cells expressing the HCRT-2 receptor.

Orexin-B-SAP is available individually (Cat. #IT-20) or as a kit (Cat. #KIT-20) which includes Orexin-B-SAP and Blank-SAP (Cat. #IT-21).

keywords: orexin, orexin receptor, hypocretin, narcolepsy, appetite, insomnia, drug addiction, anxiety, migraine, hypothalamus, OX1, OX2, orexin 1, orexin 2, HCRT, hypocretin-2, HCRT-2, Orexin-B, saporin, brain, neuroscience


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