Nodal FR, Leach ND, Keating P, Dahmen JC, Zhao D, King AJ, Bajo VM (2024) Neural processing in the primary auditory cortex following cholinergic lesions of the basal forebrain in ferrets. Hear Res 447:109025. doi: 10.1016/j.heares.2024.109025 PMID: 38733712
Objective: To explore whether behavioral deficits are associated with changes in the response properties of cortical neurons, neural activity was recorded in the primary auditory cortex (A1) of anesthetized ferrets in which cholinergic inputs had been reduced
Summary: Results show that while ACh is required for behavioral adaptation to altered spatial cues, it is not required for maintenance of the spectral and spatial response properties of A1
Usage: Bilateral injections of the immunotoxin ME20.4-SAP in the nucleus basalis (NB)
Related Products: ME20.4-SAP (Cat. #IT-15)