Smakosz A, Matkowski A, Nawrot-Hadzik I (2024) Phytochemistry and biological activities of agrostemma genus-a review. Plants (Basel) 13(12):1673. doi: 10.3390/plants13121673 PMID: 38931105
Objective: In this review, papers focused on the chemical composition and bioactivity of the two accepted species of the Agrostemma genus were examined.
Summary: A vast amount of data exists about the cytotoxicity of Agrostemma and other Caryophyllaceae plants. However, there are huge differences between models and experimental procedures, resulting in difficulty in reaching reasonable conclusions as to whether or not these properties would indeed be pharmacologically relevant for anti-cancer therapies.
Usage: Saporin inhibits HIV-1 reverse transcriptase, HIV-1 protease, and HIV-1 integrase (Au et al.). Saponins isolated from a related plant—Gypsophila sp. —enhanced the cytotoxicity of saporin 100,000-fold. This demonstrates how important the synergy of RIPs and saponins is in the toxicity of plants from Caryophyllaceae (Hebestreit et al.)
Related Products: Saporin (Cat. #PR-01)
See Also:
- Au, T.K.; Collins, R.A.; Lam, T.L.; Ng, T.B.; Fong, W.P.; Wan, D.C.C. The Plant Ribosome Inactivating Proteins Luffin and SaporinAre Potent Inhibitors of HIV-1 Integrase.FEBS Lett.2000,471, 169–172.
- Hebestreit, P.; Weng, A.; Bachran, C.; Fuchs, H.; Melzig, M.F. Enhancement of Cytotoxicity of Lectins by Saponinum Album.Toxicon2006,47, 330–335.