Branco F, Cunha J, Mendes M, Vitorino C, Sousa JJ (2024) Peptide-hitchhiking for the development of nanosystems in glioblastoma. ACS Nano 18(26):16359-16394. doi: 10.1021/acsnano.4c01790 PMID: 38861272
Objective: To review single and multiligand strategies to deliver therapeutic treatment to Glioblastoma (GBM).
Summary: The exploration of multitargeting ligands has shown great promise in GBM treatment, particularly when compared to single-targeting approaches. These ligands simultaneously use different peptides to engage a range of overexpressed receptors. These advanced strategies enhance the precision of drug delivery, facilitate BBB penetration, and enable targeting specific molecular pathways within the complex microenvironment of GBM.
Usage: ApoE-modified saporin-loaded chimeric polymersomes showed a highly efficient crossing of the BBB and accumulation in GBM.
Related Products: Saporin (Cat. #PR-01)