Doucette L, Turnbill V, Carlin K, Cavanagh A, Sollinger B, Kuter N, Flock DL, Robinson S, Chavez-Valdez R, Jantzie L, Martin LJ, Northington FJ (2024) Neocortical cholinergic pathology after neonatal brain injury is increased by Alzheimer’s disease-related genes in mice. Neurobiol Dis 200:106629. doi: 10.1016/j.nbd.2024.106629 PMID: 39111704
Objective: Authors hypothesized that neocortical damage caused by neonatal Hypoxic-ischemic (HI) in mice is ushered by persistent cholinergic innervation and interneuron (IN) pathology that correlates with cognitive outcome and is exacerbated by genes linked to Alzheimer’s disease.
Summary: Simple ChAT+axonal swellings were present in all sham and HI groups; Tg mice had more than their nTg counterparts, but HI did not affect the number of axonal swellings. In contrast, complex ChAT+neuritic clusters (NC) occurred only in Tg mice. The abundance of ChAT+ clusters in specific regions correlated with decreased Visual discrimination. This finding aligns with data that a highly specific cholinergic immunotoxin (mu p75-SAP) in the APP/PS1 mouse model worsens cognitive impairment, and the cognitive impairment appears earlier
Related Products: mu p75-SAP (Cat. #IT-16)
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