NGF in neuropathic pain: Understanding its role and therapeutic opportunities

García-Domínguez M (2025) NGF in neuropathic pain: Understanding its role and therapeutic opportunities. Curr Issues Mol Biol 47(2):93. doi: 10.3390/cimb47020093 PMID: 39996814

Objective: To determine the use of NGF as an important biomarker and therapeutic target in the management of neuropathic pain

Summary: Taking advantage of the multifaceted dynamics of NGF could provide effective pain management therapies to finally respond to the unmet needs of patients experiencing neuropathic pain. Kras et al. used saporin conjugates targeted to neurons involved in either peptidergic signaling and NGF-induced mechanical and thermal hypersensitivity in the forepaws.

Related Products: Saporin (Cat. #PR-01)

See Also:

• Kras J et al. Pain from intra-articular NGF or joint injury in the rat requires contributions from peptidergic joint afferents. Neurosci Lett 604:193-198, 2015.