Oti GO, Basak A, Eason G, Kington S, Drago C, Smith L, Osman K, Smith CL, Keilholz A, Lever TE, Nichols NL (2025) Therapeutic potential of tongue exercise on tongue force/strength during swallowing in a rodent model of hypoglossal (xii) motor neuron loss. Am Physiol Soc 40(S1) doi: 10.1152/physiol.2025.40.S1.1188
Objective: To develop a rodent model of XII axis dysfunction by administering CTB-SAP to explore potential treatment for neuromuscular disorders.
Summary: The data demonstrate that the number of evoked swallows did not differ between groups, and threshold stimulation elicited fewer swallows compared to suprathreshold intensities.
Usage: Adult male rats were intralingually injected with either 25 ug CTB-SAP (IT-14) or control (CTB unconjugated to SAP)
Related Products: CTB-SAP (Cat. #IT-14)