Kim P, Kumar V, Garner N, Jayasingh O, Roman G, Walters S, Vo T, Nguyen Q, Bowles J, Woodruff T, Inder W, Hunt J, Heyde I, Oster H, Rawashdeh O (2025) A systemic clock brake: Period1 stabilizes the circadian network under environmental stress. bioRxiv 2025.06.12.659230. doi: 10.1101/2025.06.12.659230
Objective: To investigate the role of the core circadian clock gene Period1 (Per1) in regulating light-induced circadian realignment and systemic physiological stability across central and peripheral tissues.
Summary: Per1-deficient mice showed accelerated behavioral, hormonal, and metabolic re-entrainment to shifted light-dark cycles, highlighting Per1’s role as a buffer that stabilizes circadian responses. Despite faster adaptation, Per1 deletion compromised SCN network coherence and increased peripheral metabolic phase instability.
Usage: Melanopsin (OPN4) was detected using Anti-Melanopsin (AB-N38) at a 1:2000 dilution to quantify ipRGCs in the retina and confirm that Per1-deficiency did not affect melanopsin-positive cell abundance.
Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)