Lauer LT, Decarie-Spain L, Hayes AMR, Suarez AN, Bashaw A, Klug ME, Kao AE, Cheng R, Rea JJ, Subramanian KS, Nourbash A, Donohue KN, Schier LA, Myers K, Kanoski SE (2025) The vagus nerve promotes memory via septo-hippocampal acetylcholine: Implications for obesity-induced cognitive dysfunction. bioRxiv 2025.06.11.659206.
Objective: To demonstrate that nutrient consumption promotes hippocampal-dependent memory function via vagus nerve-mediated acetylcholine (ACh) release in the dorsal hippocampus (HPCd) from medial septum (MS) neurons.
Summary: Results identify a neurobiological mechanism whereby nutrient consumption promotes memory function, and reveals that disruption of this vagal-brain signaling system mediates Western Diet-associated memory impairments.
Usage: The antineuronal immunotoxin 192-IgG-SAP, which has been validated as an agent that selectively ablates neurons that produce acetylcholine was injected in the medial septum; 200nL (0.16mg/mL) were infused in three different coordinates that span the medial septum.
Related Products: 192-IgG-SAP (Cat. #IT-01)