Lee H, Hor CC, Horwitz LR, Xiong A, Su XY, Soden DR, Yang S, Cai W, Zhang W, Li C, Radcliff C, Dinh A, Fung TLR, Rovcanin I, Pipe KP, Xu XZS, Duan B (2025) A dedicated skin-to-brain circuit for cool sensation in mice. Nat Commun 16(1):6731. doi: 10.1038/s41467-025-61562-y PMID: 40721582
Objective: To investigate the functional contributions of specific spinal dorsal horn neuron subtypes to cold and pain sensation using targeted ablation and optogenetic tools.
Summary: The study identifies Calb1+ spinal neurons as essential mediators of cool sensation in mice. Behavioral and physiological responses following targeted ablation reveal distinct sensory processing roles for various neuronal subtypes.
Usage: Bombesin-SAP (IT-40), or control conjugate Blank-SAP (IT-21), was administered intrathecally at a dose of 400 ng in 10 μL sterile saline to ablate GRPR+ spinal neurons and assess their role in sensory behavior.
Related Products: Bombesin-SAP (Cat. #IT-40), Blank-SAP (Cat. #IT-21)
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