Yu C, Li M, Shen F, Gao S, Wang J, He C, Wang L, Wu Y, Du Y (2025) Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit. Chin Med 20(1):188. doi: 10.1186/s13020-025-01230-x PMID: 41233833
Objective: To demonstrate efficacy in ameliorating Alzheimer’s disease (AD)-related cognitive dysfunction through dual peripheral and central anti-infammatory actions using electroacupuncture (EA).
Summary: Transgenic mice were administrated with EA stimulation and cognitive function was assessed via the Morris water maze and novel object recognition tests. EA at ST36 and ST37 attenuated hippocampal synaptic ultrastructural degeneration. The experimental blockade of vagal aferent neurons via CCK-SAP injection into the nodose ganglion abolished the benefits induced by EA, directly implicating GVAF signaling in the improvement of EA-mediated AD.This intervention suppressed proinflammatory cytokines expression (IL-6, IL-1β, TNF-α) and microglial hyperactivation, effectively rescuing cognitive deficits in AD models.
Usage: CCK-SAP was injected into the nodose ganglion.
Related Products: CCK-SAP (Cat. #IT-31)
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