Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8

Maria NI, Xia Y, Raparia C, Lin K, Martinez S, Yi Z, Zhang W, Aziz M, Wang P, Guerra M, Salmon, J, Sones JL, Arazi A, Hoover P, Davidson A (2026) Pregnancy loss due to early developmental defects in lupus mice expressing human TLR8. bioRxiv 2026.02.07.701591. doi: 10.64898/2026.02.07.701591

Objective: To explore human TLR8 (huTLR8) in anti-phospholipid (APL) antibody-mediated placental injury.

Summary: The authors used a novel mouse model of pregnancy loss in SLE-prone mice expressing huTLR8. Findings indicate huTLR8, likely through myeloid cell activation and cytolytic T cell recruitment, drives placental injury in the context of SLE and APL autoantibodies.

Usage: 8- to 10-week-old Sle1.CD45.1 mice were treated with biotin anti-CD117 and streptavidin-saporin

Related Products: Streptavidin-ZAP (Cat. #IT-27), Anti-CD117-SAP (Cat. #IT-83)

See Also:

• Czechowicz A et al. Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Nat Commun 10:617, 2019.