Anti-CD117-SAP [IT-83, KIT-83]

a tool for eliminating cells that express CD117 in mice; targeted via a rat monoclonal antibody to mouse CD117, eliminated via saporin

SKU: IT-83 Category: Antibody Type: Monoclonal | Host: Rat | Reactivity: Mouse | Conjugate: saporin | Usage: eliminates cells |

CD117 is a transmembrane, tyrosine kinase growth factor receptor also known as c-Kit and mast/stem cell factor receptor (SCFR). It binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia cells. CD117 plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.

Anti-CD117-SAP is a chemical conjugation of rat monoclonal CD117 antibody (Clone 2B8) and the ribosome-inactivating protein, saporin. Anti-CD117-SAP specifically eliminates cells that express CD117 in mice.

Anti-CD117-SAP is available individually (Cat. #IT-83) or as a kit (Cat. #KIT-83) which includes Anti-CD117-SAP and Rat IgG-SAP (Cat. #IT-17).