Lim-Paik C, Zeng Q, Beyea R, Boohaker R, Wang P (2026) Improving cytotoxicity of saporin with saponin SO1406 isolated from the roots of saponaria officinalis. Biomedicines 14(3):626. doi: 10.3390/biomedicines14030626
Objective: To identify structurally defined novel natural saponins and evaluate their ability to enhance anticancer cytotoxicity.
Summary: Saponins have recently emerged as promising natural products that enhance toxin-based anticancer therapeutics by improving cytosol uptake. Among the isolated compounds, SO1684 is a known saponin and SO1406 exhibited the most pronounced biological activity, significantly enhancing the cytotoxicity of the ribosome-inactivating protein saporin in the MDA-MB231 (triple-negative breast cancer) cell line.
Usage: Cells were treated with 50 mL of saporin
Related Products: Saporin (Cat. #PR-01)