Chen J, Xu T, Zhang C, Li L, He Y, Sun Z, He J, Yao Z, Cai P, Huang Y, Ye F, Guo W, Jia M, Qu J, Chen JF, Zhang Y (2026) 40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway. Cell Res doi: 10.1038/s41422-026-01227-7 PMID: 41781500
Objective: To demonstrate the multifaceted therapeutic benefits of 40 Hz light flickering as a novel non-invasive approach for pain management and reveal a distinct retina-central amygdala circuit and adenosine signaling mechanism for control of chronic pain and pain memory
Summary: The authors examined the role of intrinsically photosensitive RGCs (ipRGCs). To selectively ablate ipRGCs, melanopsin-SAP was bilaterally injected into the vitreous humor. Treated mice displayed no significant change in baseline paw withdrawal threshold. Importantly, the antinociceptive effects of 40 Hz light flickering remained intact in both CFA and SNI models, despite ablation of ipRGCs. These results indicate that ipRGCs are not essential for the analgesia induced by 40 Hz light flickering.
Usage: Melanopsin-SAP (IT-44)) was bilaterally injected into the vitreous humor.
Related Products: Melanopsin-SAP (Cat. #IT-44)