Targeting Tools: ME20.4 Monoclonal and Immunotoxin

The ME20.4 monoclonal antibody (Cat. #AB-N07) was derived from immunization of mice with WM245 melanoma cells. The antibody can be used in Western blot, immunoprecipitation, immunohistochemistry, FACS analysis, and electron microscopy. The known species reactivity includes human, primate, rabbit, raccoon, dog, cat, and sheep.

The ME20.4-SAP immunotoxin (Cat. #IT-15) is a chemical conjugation between the p75NTR monoclonal antibody and saporin, a ribosome-inactivating protein. This immunotoxin specifically eliminates p75NTR neurons in multiple species (see cover
article by Dr. Beach

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