Rabbit IgG-SAP [IT-35]

a tool for use as control for rabbit IgG-containing immunolesioning agents; non-targeted via pre-immune rabbit IgG antibody conjugated to saporin

SKU: IT-35 Category: Quantity: 25 ug, 100 ug, 250 ug | Host: rabbit | Reactivity: no known specificity | Conjugate: saporin | Usage: control |

Rabbit IgG-SAP serves as a control for targeted conjugates that use a rabbit polyclonal targeting agent. Rabbit IgG-SAP is manufactured in an identical manner as other targeted conjugates, to give a definitive baseline for comparison to the activity of the targeted conjugates listed.

Rabbit IgG-SAP serves as a control for rabbit IgG-containing immunolesioning agents.

keywords: saporin, control, IgG, rabbit, whole

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Evaluate Potential Targeting Molecules.

Kohls M (2006) Evaluate Potential Targeting Molecules. Nature Methods

Summary: Targeted toxins -- targeting agents conjugated to saporin -- are widely used to eliminate specific cell populations both in vitro and in vivo. For these molecules to be effective, it is vital that the targeting component of the conjugate specifically binds the cells of interest. A secondary conjugate, Streptavidin-ZAP, has been created by attaching the toxin saporin to streptavidin. The user can combine primary biotinylated material with Streptavidin-ZAP to quickly and economically screen potential targeting molecules for internalization and specificity. Once the appropriate targeting molecule is identified, a direct conjugation with saporin can be performed.

Related Products: Streptavidin-ZAP (Cat. #IT-27)

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Saporin as a commercial reagent: its uses and unexpected impacts in the biological sciences-tools from the plant kingdom

Ancheta LR, Shramm PA, Bouajram R, Higgins D, Lappi DA (2022) Saporin as a commercial reagent: its uses and unexpected impacts in the biological sciences-tools from the plant kingdom. Toxins (Basel) 14(3):184. doi: 10.3390/toxins14030184

Read complete article.

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