Rab-ZAP uses your primary rabbit affinity-purified polyclonal IgG antibody to target and eliminate cells that recognize your primary antibody. This secondary conjugate uses the secondary antibody (affinity-purified goat anti-rabbit IgG) to “piggyback” onto YOUR rabbit primary antibody. Rab-ZAP can be utilized for screening rabbit IgG antibodies for internalization and/or their suitability to make potent immunotoxins.
Rab-ZAP is a chemical conjugate of affinity-purified goat anti-rabbit IgG and the ribosome-inactivating protein, saporin. It uses your rabbit affinity-purified polyclonal antibody to target and eliminate cells. This secondary conjugate is used to evaluate the potential of a primary antibody to internalize.