Latest Alzheimer’s Disease research using Targeting Tools

3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain. Nizari S, Carare RO, Romero IA, & Hawkes CA. (2019). Front Aging Neurosci, 11 (172).  IT-16: mu p75-SAP

Objective:  To further characterize the effect of the loss of cholinergic innervation on the NVU (neurovascular unit) in Alzheimer’s Disease.
Summary:  Significantly less ChAT staining was detected in the medial septum of saporin-treated mice at 45 days post-surgery. This was accompanied by a significant decrease in cholinergic nerve fiber density in the hippocampus and the cortex. As expected, p75 NTR-negative neurons in the striatum were not affected by mu p75-SAP treatment.
Dose:  In this study, the mu-p75-SAP was used to induce death of basal forebrain cholinergic neurons and their fiber projections.  mu p75-SAP 0.5 µL (0.596 µg/µL) or 0.9% saline (n = 19) was injected into each ventricle.

Degeneration of ipRGCs in Mouse Models of Huntington’s Disease Disrupts Non-Image-Forming Behaviors Before Motor Impairment. Lin M-S, Liao P-Y, Chen H-M, Chang C-P, Chen S-K, & Chern Y.  (2019). J Neurosci, 39 (8):1505. AB-N38: Anti-Melanopsin

Summary:  results show that M1 ipRGCs were susceptible to the toxicity caused by mutant Huntingtin. The resultant impairment of M1 ipRGCs contributed to the early degeneration of the ipRGC–SCN pathway and disrupted circadian regulation during HD progression.
Dose:  Immunostaining (1:3000)

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