Targeting Topics

Latest research using 192-IgG-SAP to eliminate p75-positive neurons. Nitric Oxide Donor Molsidomine Promotes Retrieval of Object Recognition Memory in a Model of Cognitive Deficit Induced by 192 IgG-Saporin. (2019). Behav Brain Res, 366 108-117. Hernández-Melesio MA, Alcaraz-Zubeldia M, Jiménez-Capdeville ME, Martínez-Lazcano JC, Santoyo-Pérez ME, Quevedo-Corona L, Gerónimo-Olvera C, Sánchez-Mendoza A, Ríos C, & Pérez-Severiano F. […]

Stem cell research has great potential to understand, treat and cure diseases.  By watching stem cells mature into cells in bones, heart muscle, nerves, and other organs and tissue, researchers can determine how diseases and conditions develop.  Here are some recent publications that use ATS products to advance research involving stem cells. Figure Legend.  Non-genotoxic conditioning for hematopoietic stem cell transplantation

Glioblastoma, or glioblastoma multiforme (GBM), is a rare disease, with a global incidence of <10 per 100,000 people; the prognosis is very poor.  Here are a couple of recent studies testing targeted saporin therapies. Integrin α10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival. Munksgaard Thorén M, Chmielarska Masoumi K, Krona C,

IT-01: 192-IgG-SAP     • Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease. LID – 10.1007/s00213-018-5150-y [doi]. Koshy Cherian A et al. (2019). Psychopharmacol (Berl), [Epub ahead of print]  Dose: Basal forebrain cholinergic neurons situated in the nucleus basalis and substantia innominata were targeted with

Motor neuron diseases are a group of progressive neurological disorders that destroy motor neurons, the cells that control essential voluntary muscle activity such as speaking, walking, breathing, and swallowing. When there are disruptions in the signals between the lowest motor neurons and the muscle, the muscles do not work properly; the muscles gradually weaken and

In 1997, Melanopsin was discovered by Dr. Ignacio Provencio as a novel opsin in the melanophores (light-sensitive skin cells) of the African clawed frog.1  Provencio and colleagues then found in 2000 that melanopsin is also present in mouse retina, specifically in ganglion cells, and that it mediates non-visual photoreceptive tasks.2   The figure below illustrates the specificity

Cat. #IT-69 Nppb-SAP Meng, Qing-Tao and Liu, Xian-Yu and Liu, Xue-Ting and Barry, Devin M. and Jin, Hua and Yang, Qianyi and Sun, Yu and Wan, Li and Jin, Jin-Hua and Munanairi, Admire and Kim, Ray and Yin, Jun and Tao, Ailin and Chen, Zhou-Feng, Cross-Talk between Distinct Receptors Shapes Itch Behavior in the Spinal

Targeted Ablation of Distal Cerebrospinal Fluid-Contacting Nucleus Alleviates Renal Fibrosis in Chronic Kidney Disease.  Qiu M, Li J, Tan L, Zhang M, Zhou G, Zeng T, Li A.  Front Physiol. https://doi.org/10.3389/fphys.2018.01640 CTB-SAP (Cat. #KIT-14) CTB-SAP causes ablation of any cell type expressing GM1, including preganglionic neurons, motoneurons, and astrocytes. Intrathecal injection of CTB-SAP results in

Two more publications this week using an ATS exclusive antibody: NGFR (mu p75) Antibody (Cat. #AB-N01) Nicotinamide Mononucleotide Adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of Golgi structure. Pottorf T, Mann A, Fross S, Mansel C, & Vohra BPS. (2018). Neurochem Intl Objective:  investigated the link between NMNAT2 loss, Golgi fragmentation and axon

Two publications out this week using ATS antibodies: Anti-Melanopsin (Cat. #AB-N38) and Anti-Metabotropic Glutamate Receptor 2 (mGluR2; Cat. #AB-N32) Sabbah S, Papendorp C, Koplas E, Beltoja M, Etebari C, Gunesch AN, Carrete L, Kim MT, Manoff G, Bhatia-Lin A, Zhao T, Schreck D, Dowling H, Briggman KL, Berson DM (2018) Synaptic circuits for irradiance coding