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NGF p75 antibody for brain research

Two more publications this week using an ATS exclusive antibody: NGFR (mu p75) Antibody (Cat. #AB-N38) Nicotinamide Mononucleotide Adenylyltransferase 2 maintains neuronal structural integrity through the maintenance of Golgi structure. Pottorf T, Mann A, Fross S, Mansel C, & Vohra BPS. (2018). Neurochem Intl Objective:  investigated the link between NMNAT2 loss, Golgi fragmentation and axon […]

New Publications – Retinal Ganglion Cells and Cerebellar Purkinje Cells

Two publications out this week using ATS antibodies: Anti-Melanopsin (Cat. #AB-N38) and Anti-Metabotrophic Glutamate Receptor 2 (mGluR2; Cat. #AB-N32) Sabbah S et al.  Synaptic circuits for irradiance coding by intrinsically photosensitive retinal ganglion cells. (2018) bioRxiv  doi: https://doi.org/10.1101/442954 Objective:  To explore the synaptic networks responsible for the unique capacity of intrinsically photosensitive retinal ganglion cells (ipRGCs) to […]

Screening antibodies for cancer therapeutics

Conservation of Oncofetal Antigens on Human Embryonic Stem Cells Enables Discovery of Monoclonal Antibodies against Cancer. Tan HL, Yong C, Tan BZ, Fong WJ, Padmanabhan J, Chin A, Ding V, Lau A, Zheng L, Bi X, Yang Y, & Choo A. (2018). Scientific Reports, 8 (1):11608. This study used both Hum-ZAP (Cat. #IT-22) and Streptavidin-ZAP (Cat. #IT-27) […]

Cytoplasmic Delivery of Aptamers

Screening Aptamers as Targeting Agents to deliver Payloads. Aptamers are small, synthetic, single-stranded nucleic acids that fold into unique secondary structures. Unlike peptides and monoclonal antibodies, they are essentially non-immunogenic even when administered in excess amounts. The publications below explain how biotinylated aptamers combined with Streptavidin-conjugated saporin (Streptavidin-ZAP) can be used to screen aptamers for […]

Antibody Samples – Tools to study Programmed Cell Death

Antibodies you can rely on. The authors investigated the interactions of pro-survival and pro-apoptotic receptors in Programmed Cell Death (PCD) using the sympathetic nervous system as a model. They demonstrate that Ret, a receptor tyrosine kinase required for the survival of many neuronal populations, is restricted to a subset of degenerating neurons that rapidly undergo […]

Striatum, dopamine neurotransmission, Dermorphin, Huntington Disease

Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway. Objective:  To increase knowledge in the role of the striosomal projection onto the dopamine neurons of the SNc and its impact on the nigrostriatal dopamine pathway. Summary:  Results highlight the key function of the striosomes for maintenance of the striatal dopamine tone and […]

Breathing, Parkinson’s Disease and Targeting Orexin Receptors

Orexin-B-SAP (Cat. #IT-20): a tool for eliminating cells that express the orexin-2 receptor; targeted via orexin-B peptide, eliminated via saporin. Orexinergic Neurons Are Involved in the Chemosensory Control of Breathing During the Dark Phase in a Parkinson’s Disease Model. Oliveira LM, Falquetto B, Moreira TS, & Takakura AC (2018) Exper Neurol, 309:107-118. Objective:  To determine […]

Reliable Antibodies

3. Fujita, et al. Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model (2018). Korean J Pain.  AB-N33AP; Anti-NK-1 receptor. 4. SGrillo, et al. Melanopsin retinal ganglion cells are not labeled in Thy-1YFP-16 transgenic mice (2018). Neuroreport.  AB-N39: Anti-Melanopsin. 5. Hamano, et al. Extracellular […]

See what it’s all about: Melanopsin, retinal cells

In 1997, Melanopsin was discovered by Dr. Ignacio Provencio as a novel opsin in the melanophores (light-sensitive skin cells) of the African clawed frog.[1]  Provencio and colleagues then found in 2000 that melanopsin is also present in mouse retina, specifically in ganglion cells, and that it mediates non-visual photoreceptive tasks.[2]   Melanopsin has since been found to be […]

Antibody to the NK-1 Receptor and Postoperative Pain

Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model. Fujita M, Fukuda T, Sato Y, Takasusuki T, & Tanaka M. (2018). Korean J Pain, 31 (1):10-15. Applications include immunohistochemistry, flow cytometry, immunoblotting, and ELISA. The objective in the study published by Fujita et al. […]