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Targeting Cholinergic Neurons

Li J, Rao D, & Gibbs RB. Effects of Cholinergic Lesions and Cholinesterase Inhibitors on Aromatase and Estrogen Receptor Expression in Different Regions of the Rat Brain. (2018). Neuroscience, 384 203-213. Dose:  Rats received intraseptal injections of 2.0 ml (0.2 mg/ml) or icv injections of 0.4 mcg.  Lesions resulted in loss of ChAT-positive cells in the septum, and […]

The latest neuroscience news from Europe

Targeting Results from FENS (The Federation of European Neuroscience Societies) will be presented at this year’s meeting in Berlin. Advanced Targeting Systems congratulates the researchers on their work and looks forward to viewing the posters and interacting with scientists from around the world at this year’s meeting in Berlin. Come visit us at Booth 165 […]

Therapeutic Potential of Hematopoietic Stem Cell Gene Editing

Gene therapy has been proposed for a variety of genetic disorders, including severe combined immunodeficiency, but it has not yet found routine use in the clinic, in part because of potential complications. To help pave the way for safer translation of such gene therapy, Schiroli et al. studied potential approaches to gene therapy in mouse […]

Targeting Cancer PCI and Saporin conjugates

Enhanced Targeting of Triple-Negative Breast Carcinoma and Malignant Melanoma by Photochemical Internalization of CSPG4-Targeting Immunotoxins. Eng MS, Kaur J, Prasmickaite L, Engesaeter BO, Weyergang A, Skarpen E, Berg K, Rosenblum MG, Maelandsmo GM, Hogset A, Ferrone S, & Selbo PK. (2018). Photochemical & Photobiological Sciences 17(5):539-551. Conclusion: The combination of the drug delivery technology PCI […]

Cholinesterase Inhibitors and Estrogen Receptor Expression

Effects of Cholinergic Lesions and Cholinesterase Inhibitors on Aromatase and Estrogen Receptor Expression in Different Regions of the Rat Brain. Li J, Rao D, & Gibbs RB. Neuroscience Available online 29 May 2018 In Press, Uncorrected Proof. Highlights This paper applied a novel UPLC–MS/MS method to detect aromatase (ARO) activity in the brain tissue. Medial […]

Targeting Pain

Agents of Interest in Pain Research Agent Target Lesioning Use 192-IgG-SAP Cat. #IT-01 p75NTR, low affinity NGFR (cholinergic basal forebrain, cerebellar Purkinje neurons, postganglionic autonomic neurons and some primary sensory neurons) Immunolesioning Anti-DBH-SAP Cat. #IT-03 Dopamine beta hydroxylase (adrenergic and noradrenergic neurons) Immunolesioning by application to either dendrites/soma or by retrograde axonal transport Anti-SERT-SAP Cat. #IT-23 […]

Target Microglia for Elimination

Morphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl- homeostasis. Ferrini F, Trang T, Mattioli TA, Laffray S, Del’Guidice T, Lorenzo LE, Castonguay A, Doyon N, Zhang W, Godin AG, Mohr D, Beggs S, Vandal K, Beaulieu JM, Cahill CM, Salter MW, De Koninck Y. (2013) Nat Neurosci 16:183-92. Research Validation with Controls ATS provides […]

CRISPR/Cas9 and Targeted Toxins

The Combinational Use of CRISPR/Cas9 and Targeted Toxin Technology Enables Efficient Isolation of Bi-Allelic Knockout Non-Human Mammalian Clones. Watanabe S, Sakurai T, Nakamura S, Miyoshi K, & Sato M. (2018). Int J Mol Sci, 19 (4). Objective:  Most genome editing systems employ transient treatment with selective drugs such as puromycin to obtain the desired genome-edited […]

Macrophage Targeting

The Critical Role of Il-10 in the Antineuroinflammatory and Antioxidative Effects of Rheum Tanguticum on Activated Microglia. Meng J, Ni J, Wu Z, Jiang M, Zhu A, Qing H, & Nakanishi H. (2018). Oxidative Medicine and Cellular Longevity, 2018 12. Objective:  To investigate anti-inflammatory and antioxidative effects of a traditional Tibetan medicine (Rheum tanguticum; RT) […]

Experimental Biology San Diego – Results of Saporin lesioning

  Experimental Biology 2018 Posters using ATS Products Brainstem pre-sympathetic neuron controls oscillatory breathing in heart failure. Del Rio R, Andrade D, Toledo C, Diaz H, Lucero C, Arce-Alvarez A. Sunday, Apr. 22, 8:30 AM; 885.13 / A480 Summary: The authors hypothesized that selective elimination of catecholaminergic neurons from RVLM (C1 cells) delay cardiac deterioration […]