Targeting Topics

Which Kit

Internalization Kits Which kit is right for your research? We can help you. Also available in Chinese | French | German | Italian | Japanese | Korean | Portuguese | Spanish Learn More ZAP Antibody Internalization KitHow It Works Biotin-Z Internalization KitHow It Works Product Kit Links

Neuroscience

The Advanced Targeting Systems targeting technology provides neuroscientists with the tools to identify, visualize, and or eliminate specific cell types. Some examples of scientific studies using ATS products include Learning and Memory, Circadian Rhythm, Sleeping and Wakefulness, Parkinson’s Disease, Alzheimer’s Disease, Addiction, Multiple Sclerosis, Pain Mechanisms, Eating and Diet. Curated Resources Saporin Uses in Neuroscience …

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Validated Antibodies: NGFR & Melanopsin

Validated Antibodies targeting NGFR and Melanopsin NGFR Antibodies NGFR (mu p75) Rabbit Polyclonal [AB-N01] AB-N01 also known as mu p75, and the affinity-purified version, AB-N01AP recognize the p75 receptor in mouse. Applications include immunohistochemistry, immunoprecipitation, immunoblotting, flow cytometry, and blocking the function of nerve growth factor receptor. NGFR (ME20.4, p75) Mouse Monoclonal [AB-N07] AB-N07 also known …

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Screening targeting agents and their cell surface biomarkers for high specificity and rapid internalization via cell death and fluorescence.

Screening targeting agents and their cell surface biomarkers for high specificity and rapid internalization via cell death and fluorescence. Ancheta L, Bouajram R, Lappi DA (2018) Society for Neuroscience, San Diego, CA. Abstract Some of the most recent successes in the treatment of cancers or research into passive immunotherapies for neurodegenerative diseases, employ the use …

Screening targeting agents and their cell surface biomarkers for high specificity and rapid internalization via cell death and fluorescence. Read More »

Elimination of NPYR+ Neurons with NPY-Saporin : A Review of the Literature

Elimination of NPYR+ Neurons with NPY-Saporin : A Review of the Literature Patrick A. Shramm, Denise Higgins, Douglas A. Lappi • Advanced Targeting Systems, Carlsbad, CA Abstract Introduction: NPY-SAP is a conjugate of Neuropeptide Y and the ribosome-inactivating protein (RIP) saporin. The idea behind the invention of NPY-SAP is to introduce it using the ligand’s …

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Anti-Melanopsin Staining

Intrinsically photosensitive retinal ganglion cells (ipRGCs) contain melanopsin. The ipRGCs, with their amazing long processes, are involved in the perception of light and dark and are circadian rhythm determinants. Anti-Melanopsin staining on either flat-mount or cross-section staining of mouse retina.

A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors.

A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Shramm PA, Ancheta L, Higgins D, Lappi DA (2017) Society for Neuroscience, Washington, DC. Abstract Some of the most recent successes in the treatment of cancers have been from antibodies to cell surface proteins …

A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Read More »

Streptavidin-pHast: A readily conjugatable, pH-sensitive dye to screen for internalization

Streptavidin-pHast: A readily conjugatable, pH-sensitive dye to screen for internalization Shramm PA, Ancheta L (2019) Proceedings of the American Association for Cancer Research Annual Meeting, Atlanta GA. Abstract The quick and efficient screening of targeting agents that internalize effectively is vital for determining suitability as potential therapeutics. Some of the most recent successes in the …

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Saporin Uses in Immunology

One of the more common methods of using Streptavidin-ZAP is to couple the complex with biotinylated antibodies. However, there are also many instances of biotinylated ligands, peptides, and even biotinylated major histocompatibility complex (MHC) tetramers in immunology fields. B-Cell Targeting. An example of utilizing Streptavidin-ZAP to study ligands that target CD22 were shown by Collins …

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Immunology

NGFr (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07) The p75 neurotrophin receptor (p75NTR), also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective …

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