Targeting Topics

Neuroscience 2021 and Targeting Trends

Have you read Targeting Trends newsletters? Now in a more convenient format, the ATS newsletters are accessible on our website. Features include summaries of the latest publications, FAQ to answer product questions, and articles with cutting edge research shared by featured scientists. Plus cameo appearances by our beloved cats. Flip through the pages of the newsletters like …

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New Publications using Saporin conjugates

Cat. #IT-01  192-IgG-SAP Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats. Dezawa S, Nagasaka K, Watanabe Y, & Takashima I. (2020). Exp Neurol, 335 113493. 2020/10/05.  Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits. Moschonas EH, Leary JB, …

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World Alzheimer’s Month – Latest publications

Cat. #IT-01  192-IgG-SAP Long-term potentiation in the hippocampal CA3 to CA1 synapses may be induced in vivo by activation of septal cholinergic inputs. Dobryakova, Y. V., M. Y. Stepanichev, V. A. Markevich and A. P. Bolshakov (2020).  Int J Neurosci: 1-9. Intracerebroventricular Administration of 192IgG-Saporin Alters the State of Microglia in the Neocortex. Volobueva, M. N., Y. …

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Your back-up laboratory team is here

Assay and Conjugation Services Restricted access can slow or halt your research and drug development activities.  We can help!  Here is just one of the services CytoLogistics provides to research and drug development laboratories around the world.    Cell Transfections Transfections can be a time-consuming and tedious process.  Let CytoLogistics help you with the experimental …

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Tools and Services to Advance your Research and Drug Development

TOOLS FOR SELECTIVELY ALTERING CELLS BASED ON CELL-SURFACE MARKERS You’re still publishing and we’re still open to meet your targeting needs.  You can place your orders online or contact us. Stay safe and healthy!Denise Higginswww.ATSbio.com SERVICES FOR SELECTIVELY ALTERING AND ASSAYING CELLS Restricted access can slow or halt your research and drug development activities.  We …

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Recent Publications using ATS Products

Borkowski LF, & Nichols NL. A2A and 5-HT Receptors are Differentially Required for Respiratory Plasticity Over the Course of Motor Neuron Loss in Intrapleurally CTB-SAP Treated Rats. (2019). FASEB J, 33 (1_supplement):843.843-843.843. IT-14: CTB-SAP Dose: Bilateral, intrapleural injections of: 1) CTB-SAP (25 μg), or 2) un-conjugated CTB and SAP (control) in rats. Toledo C, Andrade …

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Alzheimer’s Disease models

A review of the tools for creating animal models of Alzheimer’s Disease “192 IgG-saporin binds selectively and irreversibly to low-affinity nerve growth factor receptor interrupting cholinergic neuronal protein synthesis.” “Anti-DBH-SAP allows a selective and gradual lesioning of noradrenergic neurones in the brain stem nucleus locus coeruleus, the primary site of noradrenaline production in the CNS.” …

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Award winner for animal model of temporal lobe epilepsy

Congratulations to Dr. Argyle Bumanglag and the team at University of Florida for the important work they presented using SSP-SAP to create an animal model of temporal lobe epilepsy. Injections of SSP-SAP into the hippocampus of a rat causes acute hippocampal injury, permanent dentate granule cell-onset epilepsy, and hippocampal sclerosis that closely resembles the selective …

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