Targeting Topics – Advanced Targeting Systems

pHast Conjugates – Key Features. Real Advantages.

Key Features. Real Advantages. Internalization data is only useful if you can trust what you’re seeing. Because pHast Conjugates activate specifically in acidic intracellular compartments, they help distinguish internalized material from surface-bound signal and reduce the background that can complicate interpretation with traditional assays. The result is a clearer, more biologically relevant readout of internalization […]

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pHast Conjugates – Broad Compatibility. Clear Results.

Targeting Topics / Kristen Hartman

One Platform. Multiple Workflows. pHast Conjugates are designed to support a range of internalization workflows across different targeting materials and assay platforms. Researchers can use Fab-pHast to evaluate antibody fragments or Streptavidin-pHast to assess biotinylated targeting materials, including antibodies, peptides, and other compatible formats. The assay is also adaptable across multiple readout platforms, including microscopy, flow cytometry, and high-throughput screening.

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pHast Conjugates – Workflow.

Targeting Topics / Kristen Hartman

True internalization. pHast Conjugates were built to answer a simple but critical question: did your targeting material actually internalize? The pHast reporter is designed to remain silent at neutral pH and activate only after internalization into acidic intracellular compartments such as endosomes and lysosomes. That means you can distinguish true internalization from surface-bound signal and

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pHast Conjugates – Less Guessing. More Knowing.

Targeting Topics / Kristen Hartman

Less Guessing. More Knowing. Determining whether a targeting material truly internalizes can be one of the biggest challenges in early-stage evaluation. Binding alone does not guarantee internalization, and traditional fluorescent assays often create more uncertainty than clarity. Surface-bound signal, background fluorescence, and complex wash steps can all make it difficult to know which candidates are

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Cancer Research

Targeting Topics / Kristen Hartman

Antibody Drug Conjugates to Treat Cancer A Brief History of Saporin and its Contributions to Neuroscience Targeted Toxins – Cheaper and Quicker than Knockouts A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Screening targeting agents and their cell surface biomarkers for high

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Antibody Drug Conjugates to Treat Cancer

Targeting Topics / Kristen Hartman

Antibody Drug Conjugates to Treat Cancer Antibody Screening for Cancer Research and Drug Development There is a growing need for therapeutics for cancer, autoimmune diseases, blood diseases and Alzheimer’s disease. Due to their ability to bind to a specific target antigen, monoclonal antibodies are increasingly being screened for therapeutic drug development. In May 2021, the

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Which Kit

Targeting Topics, Video / Phil Higgins

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Neuroscience

Targeting Topics / Kristen Hartman

The Advanced Targeting Systems targeting technology provides neuroscientists with the tools to identify, visualize, and or eliminate specific cell types. Some examples of scientific studies using ATS products include Learning and Memory, Circadian Rhythm, Sleeping and Wakefulness, Parkinson’s Disease, Alzheimer’s Disease, Addiction, Multiple Sclerosis, Pain Mechanisms, Eating and Diet. Learning and Memory Galanin-SAP [IT-34] PACAP-SAP

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Validated Antibodies: NGFR & Melanopsin

Targeting Topics / Kristen Hartman

Validated Antibodies targeting NGFR and Melanopsin NGFR Antibodies NGFR (mu p75) Rabbit Polyclonal [AB-N01] AB-N01 also known as mu p75, and the affinity-purified version, AB-N01AP recognize the p75 receptor in mouse. Applications include immunohistochemistry, immunoprecipitation, immunoblotting, flow cytometry, and blocking the function of nerve growth factor receptor. NGFR (ME20.4, p75) Mouse Monoclonal [AB-N07] AB-N07 also known

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Screening targeting agents and their cell surface biomarkers for high specificity and rapid internalization via cell death and fluorescence.

Targeting Topics / Kristen Hartman

Screening targeting agents and their cell surface biomarkers for high specificity and rapid internalization via cell death and fluorescence. Ancheta L, Bouajram R, Lappi DA (2018) Society for Neuroscience, San Diego, CA. Abstract Some of the most recent successes in the treatment of cancers or research into passive immunotherapies for neurodegenerative diseases, employ the use

Screening targeting agents and their cell surface biomarkers for high specificity and rapid internalization via cell death and fluorescence. Read More »