A review of the tools for creating animal models of Alzheimer’s Disease “192 IgG-saporin binds selectively and irreversibly to low-affinity nerve growth factor receptor interrupting cholinergic neuronal protein synthesis.” “Anti-DBH-SAP allows a selective and gradual lesioning of noradrenergic neurones in the brain stem nucleus locus coeruleus, the primary site of noradrenaline production in the CNS.” […]
Alzheimer’s Disease models Read More »
Congratulations to Dr. Argyle Bumanglag and the team at University of Florida for the important work they presented using SSP-SAP to create an animal model of temporal lobe epilepsy. Injections of SSP-SAP into the hippocampus of a rat causes acute hippocampal injury, permanent dentate granule cell-onset epilepsy, and hippocampal sclerosis that closely resembles the selective
2019 Poster of the Year Read More »
Come visit us at The Society for Neuroscience in Chicago – October 19-23, Booth #763. We have some exciting new products to talk to you about. Cell Transfection Kit & Service Temporal Lobe Epilepsy Animal Model
New product announcements at SfN: Transfection and Epilepsy tools Read More »
The Society for Neuroscience meeting is just around the corner. Come visit us in Chicago – October 19-23, Booth #763. Here is a list of the posters competing for the Annual Post of the Year Award using ATS products. (click to zoom) Saturday, October 19 Sunday, October 20 Monday, October 21 Tuesday, October 22 Wednesday,
SfN Poster of the Year Contenders Read More »
Fab-pHast products bind to your primary antibody via a secondary antibody or Streptavidin cross-linked to a pH-dependent fluorescent reporter. This fluorescent reporter increases intensity as the pH of its surroundings becomes more acidic, as evident when exposed to the environment inside a cell. SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked
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Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-Yloxy)Phenyl]-2-(Morpholin-4-Yl)Acetamide Dihydrochloride (Suvn-G3031): A Novel, Potent, Selective, and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity. (2019). J Med Chem, 62 (3):1203-1217. Nirogi R, Shinde A, Mohammed AR, Badange RK, Reballi V, Bandyala TR, Saraf SK, Bojja K, Manchineella S, Achanta PK, Kandukuri KK, Subramanian R, Benade V,
Orexin-SAP Model of Sleep Disorders Read More »
Leptin receptor-expressing neurons in the ventromedial nucleus of the hypothalamus contribute to weight loss caused by fourth ventricle leptin infusions. (2019). Am J Physiol Endocrinol Metab PMID: 31361549Seamon M, Ahn W, Li A-J, Ritter S, & Harris RBS. IT-47: Leptin-SAP Objective: To test the importance of VMH leptin responsiveness in mediating weight loss caused by fourth ventricle
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Neuroprotective Effects of Exercise on the Morphology of Somatic Motoneurons Following the Death of Neighboring Motoneurons. (2019). Chew C, & Sengelaub DR. Neurorehabil Neural Repair, epub ahead of print 1545968319860485. IT-14: CTB-SAP Objective: To explore whether exercise shows the same neuroprotective effect on induced dendritic atrophy as that seen with androgen treatment.Summary: Exercise following neural
Neuroprotective Effects of Exercise Read More »
Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. (2019). Cell Reports, 28 (3):625-639.e626. Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, Eva C, & Goulding M. Objective: To determine the central pathway for mechanical itch.Summary: NPY-Y1 signaling regulates the transmission of innocuous tactile information by establishing biologically relevant thresholds for
Latest Itch research using Targeted Toxins Read More »
3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain. Nizari S, Carare RO, Romero IA, & Hawkes CA. (2019). Front Aging Neurosci, 11 (172). IT-16: mu p75-SAP Objective: To further characterize the effect of the loss of cholinergic innervation on the NVU
Latest Alzheimer’s Disease research using Targeting Tools Read More »