Targeted Ablation of Distal Cerebrospinal Fluid-Contacting Nucleus Alleviates Renal Fibrosis in Chronic Kidney Disease. Qiu M, Li J, Tan L, Zhang M, Zhou G, Zeng T, Li A. Front Physiol.
CTB-SAP (Cat. #KIT-14)
CTB-SAP causes ablation of any cell type expressing GM1, including preganglionic neurons, motoneurons, and astrocytes. Intrathecal injection of CTB-SAP results in elimination of oligodendrocytes and astrocytes and the subsequent demyelination of the spinal cord. CTB-SAP allows the study of a number of demyelinating conditions.
CTB-SAP eliminates cells that express the receptor to Galactosyl-N-Acetylgalactosaminyl.