CTB-SAP and Targeted Ablation of dCSF-CNs

Targeted Ablation of Distal Cerebrospinal Fluid-Contacting Nucleus Alleviates Renal Fibrosis in Chronic Kidney Disease.  Qiu M, Li J, Tan L, Zhang M, Zhou G, Zeng T, Li A.  Front Physiol.
https://doi.org/10.3389/fphys.2018.01640

Figure: Representative images of dCSF-CNs in the brainstem by cholera toxin B (CTB) immunoreactive immunofluorescence after an icv injection of CTB-SAP.


CTB-SAP (Cat. #KIT-14)

CTB-SAP causes ablation of any cell type expressing GM1, including preganglionic neurons, motoneurons, and astrocytes. Intrathecal injection of CTB-SAP results in elimination of oligodendrocytes and astrocytes and the subsequent demyelination of the spinal cord. CTB-SAP allows the study of a number of demyelinating conditions.

CTB-SAP eliminates cells that express the receptor to Galactosyl-N-Acetylgalactosaminyl.