NGFR (mu p75) Rabbit Polyclonal, affinity-purified [AB-N01AP]

$475.00

SKU: AB-N01AP Category: Quantity: 50 ug | Antibody Type: affinity-purified, Polyclonal | Host: rabbit | Reactivity: mouse | Conjugate: unconjugated | Usage: flow cytometry, immunohistochemistry |

The p75 neurotrophin receptor (p75NTR), also known as the low affinity nerve growth factor receptor, binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NTR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death.

This antibody recognizes p75NTR in mouse. The antisera was developed in rabbit using an extracellular fragment from the mouse p75 receptor (amino acids 43-161). The antibody was affinity-purified using the extracellular domain of p75. The antibody is routinely tested by flow cytometry.

Applications include immunohistochemistry, flow cytometry, and targeting.

keywords: P75NTR, NGFR, Alzheimer’s Disease, dementia, CBF neurons, cholinergic forebrain, animal model, neuronal loss, low affinity nerve growth factor, neurotrophin receptors, mesenchyme, Anti-NGFR, Anti-Nerve Growth Factor, mup75, mu p75, brain, neuroscience

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Expression pattern of brain-derived neurotrophic factor and its associated receptors: Implications for exogenous neurotrophin application

Schulze J, Staecker H, Wedekind D, Lenarz T, Warnecke A (2022) Expression pattern of brain-derived neurotrophic factor and its associated receptors: Implications for exogenous neurotrophin application. Hear Res 413:108098. doi: 10.1016/j.heares.2020.108098 PMID: 33143996

Objective: To investigate the mechanisms of brain-derived neurotrophic factor (BDNF) in the inner ear, by analyzing the expression of mature BDNF (mBDNF), its proform proBDNF and their respective receptors the low affinity p75 neurotrophin receptor (p75NTR) and the neurotrophic receptor tyrosine kinase 2 (NTRK2).

Summary: Treatment with proBDNF is not toxic for spiral ganglion neuron (SGN) survival but simultaneously not protective. However, combined treatment of mBDNF and proBDNF maintained and perhaps slightly increased the protective effect of mBDNF.

Usage: Immunohistochemistry (1:250); AB-N01AP: NGFr (mu p75) Rabbit Polyclonal

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice

Li Y, Hollis E (2021) Basal forebrain cholinergic neurons selectively drive coordinated motor learning in mice. J Neurosci 41(49):10148-10160. doi: 10.1523/JNEUROSCI.1152-21.2021 PMID: 34750228

Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP), mu p75-SAP (Cat. #IT-16)

Purification of fibroblasts from the spiral ganglion

Anacker A, Esser KH, Lenarz T, Paasche G (2022) Purification of fibroblasts from the spiral ganglion. Front Neurol 13:877342. doi: 10.3389/fneur.2022.877342 PMID: 35493807

Objective: To provide a purified preparation of cochlear fibroblasts, which can be used in vitro for further investigations.

Summary: Subcultivation of the primary spiral ganglion cells culture removed the neurons from the culture and increased the fibroblast to glial cell ratio in the preparations. Direct immunolabeling for the Thy1-glycoprotein and the p75NGFR-enabled fluorescence-based cell sorting. This resulted in a cell culture of cochlear fibroblasts with a purity of more than 99%.

Usage: Cell Sorting (1:400)

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NGFR Products:

NGFR (192-IgG, p75) Mouse Monoclonal (Cat. #AB-N43) | Cy3-labeled (Cat. #AB-N43-FL3) | Alexa488-labeled (Cat. #AB-N43-FLA)

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NGFR (ME20.4, p75) Mouse Monoclonal (Cat. #AB-N07) | biotin-labeled (Cat. #AB-N07-BT) | Alexa488-labeled (Cat. #AB-N07-FLA)

192-IgG-SAP (Cat. #IT-01)

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