Targeting Tools: Top Twenty of 2018 – Advanced Targeting Systems

Top Five Targeted Toxins

1. CTB-SAP (Cholera Toxin B-Saporin) (Cat. #IT-14) – targets cells expressing GM1 receptor

2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase (DBH)

3. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) – targets cells expressing rat p75NTR

4. Anti-ChAT-SAP (Cat. #IT-42) – targets cells expressing choline acetyltransferase

5. Nppb-SAP (Neuropeptide natriuretic polypeptide B) (Cat. #IT-06) – targets cells expressing Nppb or BNP receptor

Phrenic motor neuron counts in controls and CTB-SAP treated rats after 7 and 28 days. A-C. Representative CTB-stained sections from C4 spinal ventral horn from a control rat (A) Control, (B) 7-day, (C) 28-day. Phrenic motor neuron survival is significantly decreased in CTB-SAP treated rats versus control rats (*; p < 0.05), but was not different when comparing 7 and 28 day CTB-SAP treated rats (p > 0.05). Means ± 1 SEM. Scale bar at 20X = 50 μm.
Nichols et al. Respir Physiol Neurobiol 256:43, 2018.

Top Five Antibodies

1. Angiotensin II receptor (AT-1r) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

2. Trans-hydroxyproline Rabbit Polyclonal (Cat. #AB-T044)

3. Melanopsin Rabbit Polyclonal (Cat. #AB-N38)

4. NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

5. Angiotensin II receptor (AT-2r) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)

AB-N27AP (Angiotensin IIR – AT1R. Photomicrographs in A,B) and C,D) represent low and high magnification, respectively; images of IHC localization of AT1R in left and right basolateral amygdala of an adult male rat. Black box inserts in A and B are high magnification photomicrographs shown in C and D, respectively. Black box inserts in C and D are higher magnification images of neurons in C and D that are indicated by arrows. Scale bars: 200 μm, A,B; 50 μm, C,D.
Johnson et al. Prog Neuro-Psychopharmacol Biol Psychiatry, 44:248, 2013.

Top Five ZAP Products

1. Streptavidin-ZAP (Cat. #IT-27) – Uses your biotinylated material in order to evaluate the ability of the reagent to internalize upon binding to its receptor

2. FAB-ZAP human (Cat. #IT-51) – Uses your primary human monoclonal antibody

3. FAB-ZAP mouse (Cat. #IT-48) – Uses your primary mouse monoclonal antibody

4. Mab-ZAP (Cat. #IT-04) – Uses your primary mouse monoclonal antibody

5. Fab-ZAP rat (Cat. #IT-55) – Uses your primary rat monoclonal IgG antibody

Top Five in Number of Publications

1. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) – targets cells expressing rat p75NTR

2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase (DBH)

3. Streptavidin-ZAP (Cat. #IT-27) – Uses your biotinylated material in order to evaluate the ability of the reagent to internalize upon binding to its receptor

4. NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)

5. Melanopsin Rabbit Polyclonal (Cat. #AB-N38)