Mac-1-SAP mouse/human [IT-06]

25 ug, 100 ug, 250 ug, 1 mg

a tool for eliminating cells that express Mac-1 (CD11b) receptor in mouse or human; targeted via the antibody to CR3 (CD11b), eliminated via saporin

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SKU: IT-06 Category:

Description

CD11b is an alpha subunit of Mac-1, also known as CR3. CD11b is the receptor for the C3bi fragment of complement. This receptor is involved in bacterial phagocytosis. A reduction in neutrophil CD11b expression after severe traumatic injury correlates with increased septic complications. CD11b is a component of integrins, important for adhesion of neutrophils to surfaces. Mac-1-SAP recognizes the Mac-1 (CD11b) receptor in mouse and human. Mac-1-SAP is excellent for removing contaminating macrophages from primary cultures to determine their role(s) in autoimmune diseases and in degenerative diseases such as Alzheimer’s.

Mac-1-SAP eliminates Mac-1 positive (CD11b positive) cells. All other cells are left untouched.

To eliminate Mac-1-positive cells in rat, use Mac-1-SAP rat (Cat. #IT-33).

To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols

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