Mac-1-SAP mouse/human [IT-06, KIT-06]

a tool for eliminating cells that express Mac-1 (CD11b) receptor in mouse or human; targeted via the antibody to CR3 (CD11b), eliminated via saporin

SKU: IT-06 Categories: , Antibody Type: Monoclonal | Host: Rat | Reactivity: Human, Mouse | Conjugate: saporin | Usage: eliminates cells |

CD11b is an alpha subunit of Mac-1, also known as CR3. CD11b is the receptor for the C3bi fragment of complement. This receptor is involved in bacterial phagocytosis. A reduction in neutrophil CD11b expression after severe traumatic injury correlates with increased septic complications. CD11b is a component of integrins, important for adhesion of neutrophils to surfaces. Mac-1-SAP recognizes the Mac-1 (CD11b) receptor in mouse and human. Mac-1-SAP is excellent for removing contaminating macrophages from primary cultures to determine their role(s) in autoimmune diseases and in degenerative diseases such as Alzheimer’s.

Mac-1-SAP is a chemical conjugate of the rat monoclonal antibody to CD11b (the receptor for C3bi) and the ribosome-inactivating protein, saporin. It eliminates Mac-1 positive (CD11b positive) cells in mouse and human.

To eliminate Mac-1-positive cells in rat, use Mac-1-SAP rat (Cat. #IT-33).

Mac-1-SAP mouse/human is available individually (Cat. #IT-06) or as a kit (Cat. #KIT-06) which includes Mac-1-SAP and Rat IgG-SAP (Cat. #IT-17).