Mac-1-SAP mouse/human [IT-06, KIT-06]

CD11b is an alpha subunit of Mac-1, also known as CR3. CD11b is the receptor for the C3bi fragment of complement. This receptor is involved in bacterial phagocytosis. A reduction in neutrophil CD11b expression after severe traumatic injury correlates with increased septic complications. CD11b is a component of integrins, important for adhesion of neutrophils to surfaces. Mac-1-SAP recognizes the Mac-1 (CD11b) receptor in mouse and human. Mac-1-SAP is excellent for removing contaminating macrophages from primary cultures to determine their role(s) in autoimmune diseases and in degenerative diseases such as Alzheimer’s.

Mac-1-SAP is a chemical conjugate of the rat monoclonal antibody to CD11b (the receptor for C3bi) and the ribosome-inactivating protein, saporin. It eliminates Mac-1 positive (CD11b positive) cells in mouse and human.

Mac-1-SAP mouse/human is available individually (Cat. #IT-06) or as a kit (Cat. #KIT-06) which includes Mac-1-SAP and Rat IgG-SAP (Cat. #IT-17).

Mac-1 (CD11b) Products:

Mac-1 (CD11b) Rat Monoclonal (Cat. #AB-N05) | biotin-labeled (Cat. #AB-N05-BT) | Alexa488-labeled (Cat. #AB-N05-FLA)

Mac-1-SAP mouse/human (Cat. #IT-06)

keywords: Mac-1, CD11b, C3bi receptor, microglia, macrophages, CR3, Anti-Mac-1, Anti-CD11b, Anti-CR3, saporin, targeted toxin, Alzheimer’s disease.