Mac-1 (CD11b) Rat Monoclonal, Alexa488 labeled [AB-N05-FLA]


SKU: AB-N05-FLA Categories: , Quantity: 50 ug | Antibody Type: Monoclonal | Host: rat | Reactivity: human, mouse | Conjugate: Alexa488 | Usage: binding assay, cytotoxicity assay, flow cytometry, immunoprecipitation |

CD11b is an alpha subunit of Mac-1, also known as CR3. CD11b is the receptor for the C3bi fragment of complement. This receptor is involved in bacterial phagocytosis. A reduction in neutrophil CD11b expression after severe traumatic injury correlates with increased septic complications. CD11b is a component of integrins, important for adhesion of neutrophils to surfaces. Mac-1 exists as a chemoattractant activation-dependent molecule that undergoes a conformational change upon stimulation. Expression of new epitopes on Mac-1 can be detected after activation by specific reporter monoclonal antibodies. Until stimulation occurs, Mac-1 remains in a resting, non-adhesive state. Activation of Mac-1 may play a role during neutrophil recruitment to the inflamed site.

This antibody recognizes human and mouse Mac-1 (CD11b). The hybridoma was formed by the fusion of mouse myeloma NS1 cells with spleen cells from rats immunized with B10 mouse spleen cells enriched for T-lymphocytes. It has been conjugated to the fluorescent dye Alexa488. The antibody is routinely tested by flow cytometry.

Applications include immunoprecipitation, flow cytometry, cytotoxicity assay, and binding assay.

Mac-1 (CD11b) Products:

Mac-1 (CD11b) Rat Monoclonal (Cat. #AB-N05) | biotin-labeled (Cat. #AB-N05-BT) | Alexa488-labeled (Cat. #AB-N05-FLA)

Mac-1-SAP mouse/human (Cat. #IT-06)

keywords: Mac-1, CD11b, C3bi receptor, microglia, macrophages, CR3, Anti-Mac-1, Anti-CD11b, Anti-CR3, fluorescent, Alexa488, brain, neuroscience


There are no reviews yet.

Be the first to review “Mac-1 (CD11b) Rat Monoclonal, Alexa488 labeled [AB-N05-FLA]”

View Data Sheet

browse all references for this product | back to top

browse all protocols and calculators | back to top

Shopping Cart
Scroll to Top