Targeting Tools: Mac-1-SAP

The Mac-1-SAP targeted toxins recognize Mac-1-positive (CD11b) cells in mouse/human (Cat. #IT-06) or in rat (Cat. #IT-33). The toxin is excellent for removing contaminating macrophages from primary cultures. Elimination of macrophages in vivo is useful to determine their role(s) in autoimmune diseases and in degenerative diseases such as Alzheimer’s. Both toxins are extremely potent, with EC50’s three to five orders of magnitude less than non-targeted saporin.

The Mac-1-SAP mouse/human-specific antibody (Cat. #AB-N05) is from the well-characterized M1/70 clone, and has been created by immunization from mouse macrophages, but reacts well with the human epitope also. It does not recognize the rat form. The antibody is also available biotin-labeled (Cat. #BT-N05) and Alexa488-labeled (Cat. #FL- N05).

The Mac-1-SAP rat-specific antibody (Cat. #AB-N06) was developed in mice immunized with rat neutrophils. It does not cross-react with the human or mouse epitope. The antibody is also available biotin-labeled (Cat. #BT-N06) and Alexa488-labeled (Cat. #FL-N06).