CD11b is an alpha subunit of Mac-1, also known as CR3. CD11b is the receptor for the C3bi fragment of complement. This receptor is involved in bacterial phagocytosis. A reduction in neutrophil CD11b expression after severe traumatic injury correlates with increased septic complications. CD11b is a component of integrins, important for adhesion of neutrophils to surfaces. Mac-1-SAP recognizes the Mac-1 (CD11b) receptor in mouse and human. Mac-1-SAP is excellent for removing contaminating macrophages from primary cultures to determine their role(s) in autoimmune diseases and in degenerative diseases such as Alzheimer’s.
Mac-1-SAP is a chemical conjugate of the rat monoclonal antibody to CD11b (the receptor for C3bi) and the ribosome-inactivating protein, saporin. It eliminates Mac-1 positive (CD11b positive) cells in mouse and human.
To eliminate Mac-1-positive cells in rat, use Mac-1-SAP rat (Cat. #IT-33).