Contributed by L.S. Sorkin, J.-I. Choi, and F.J. Koehrn, Univ. California San Diego, La Jolla, CA Paw inflammation with carrageenan elicits phosphorylation of Akt in spinal cord neurons with an unusual time course (Choi et al., 2010). Activation of Akt is seen first in neurons of the superficial dorsal horn and in α-motor neurons, followed […]
Anti-dopamine beta-hydroxylase-saporin (anti-DBH-SAP, Cat. #IT-03) is a highly specific noradrenergic lesioning agent. It specifically targets rat cells that express dopamine beta-hydroxylase and is also reported to react with mouse protein.1 This vesicular enzyme is exposed to the exterior milieu upon release of noradrenaline and thus allows these cells to be targeted with saporin. The specificity
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Contributed by Lisa E. Goehler and Ronald P.A. Gaykema Center for the Study of Complementary and Alternative Therapies, University of Virginia School of Nursing, Charlottesville, VA 22908 Fatigue, experienced as reduced motivation and motor activity, is common in acute and chronic disease, including heart disease, cancer and cancer chemotherapy. Fatigue is part of a constellation
Read the 2010 Newsletters and recent scientific references 2010, issue 1: 2010, issue 2: 2010, issue 3: 2010, issue 4:
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Awarded by ATS at Society for Neuroscience (SFN) November 14-17, 2010 • San Diego, CA 331.5/B19 Functional cholinergic neurons from human embryonic stem cellsY Liu, R Krencik, H Liu, L Ma, X Zhang, S-C Zhangfeaturing IT-16 mu p75-SAP (Poster; Monday, Nov. 15, 8:00 am – 9:00 am) Basal forebrain cholinergic neurons play a critical role
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GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving g-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy,
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Advanced Targeting Systems, the company that pioneered the targeting of specific cell types to manipulate them for the treatment of diseases and for research into the function of biological systems, has been awarded $3 million from the National Cancer Institute (NCI). Representatives from the NCI stated that the Advanced Targeting Systems proposal was ranked #1
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Contributed by Heidi L. Lujan and Stephen E. DiCarloDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 Excessive sympathetic activity is responsible for, and/or contributes to, the morbidity and mortality associated with cardiovascular diseases (e.g. hypertension, stroke, heart failure, ischemic heart disease, ventricular arrhythmias). For example, myocardial ischemia provokes a powerful reflex
CTB-SAP (Cat. #IT-14) is a conjugate between the cell-binding component of cholera toxin (the B chain) and saporin. CTB binds to GM1 (monosialotetrahexosylganglioside), which is present on the surface of different neurons. It has been suggested to be involved in many problems (besides the most famous in the gut: cholera) of neuronal systems: Parkinson’s, motor
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