Top Five Targeted Toxins #1. CTB-SAP (Cat. #IT-14) – targets cells expressing GM1 receptor #2 Mac-1-SAP (Cat. #IT-06) – targets cells expressing Mac-1 (CD11b ) receptor #3 Anti-CD103-SAP (Cat. #IT-50) – targets cells expressing CD103 #4. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase #5. mu p75-SAP (Cat. #IT-16) – targets cells expressing mouse […]
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Top Five Targeted Toxins #1. CTB-SAP (Cat. #IT-14) – targets cells expressing GM1 receptor #2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase #3. IB4-SAP (Cat. #IT-10) – targets cells expressing alpha-D-galactopyranoside residues #4. mu p75-SAP (Cat. #IT-16) – targets cells expressing mouse p75NTR #5. ME20.4-SAP (Cat. #IT-15) – targets cells expressing multiple mammalian
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Antibody-Saporin Conjugates (able to be retrogradely transported) Saporin Conjugate(s) Molecular Target Cell Subpopulation Killed References 192-IgG-SAP(192-Saporin) Nerve growth factorreceptor (NGFR),p75NTR Rat cholinergic forebrain neuronsUpper cervical ganglion Cat. #IT-01 Anti-ChAT-SAP(ChAT-SAP) Cholineacetyltransferase(ChAT) Cholinergic interneurons ofdorsal striatum Cat. #IT-42 Anti-DAT-SAP(DAT-SAP) Dopamine Transporter(DAT) Dopaminergic neuronsParkinson’s disease Model Cat. #IT-25 Anti-DBH-SAP(DSAP) Dopamine betahydroxylase (DBH) Locus coeruleus/subcoeruleusAlzheimer’s disease Model Cat. #IT-03
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Top Five Targeted Toxins #1. CTB-SAP (Cat. #IT-14) – targets cells expressing GM1 receptor #2. 192-IgG-SAP (Cat. #IT-01) – targets cells expressing rat p75NTR #3. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase #4. IB4-SAP (Cat. #IT-10) – targets cells expressing alpha-D-galactopyranoside residues #5. CCK-SAP (Cat. #IT-06) – targets cells expressing sulfonated Cholecystokinin Top Five
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Advanced Targeting Systems and its Contract Service partner, CytoLogistics announce a Call For Proposals for research collaborations on: Receptor-mediated Delivery: New Targets Selected researchers will receive support for smaller scale or pilot research projects ($1,000 – $25,000) with the targeting tools and contract services needed for the identification and characterization of new cell-surface markers for
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Top Five Targeted Toxins 1. CTB-SAP (Cholera Toxin B-Saporin) (Cat. #IT-14) – targets cells expressing GM1 receptor 2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase (DBH) 3. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) – targets cells expressing rat p75NTR 4. Anti-ChAT-SAP (Cat. #IT-42) – targets cells expressing choline acetyltransferase 5. Nppb-SAP (Neuropeptide natriuretic polypeptide
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ZAP Antibody Internalization Kits allow a large number of antibodies to be screened quickly and cost-effectively for specificity, functional binding, internalization, and EC50 determination. The wide selection of these secondary conjugates provide ideal tools for screening potential antibodies . They are constructed using either species-specific polyclonal anti-IgG antibodies, or streptavidin (alternate kit for use with biotinylated
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Contributed by Patrick Shramm, Product Manager for Fab-pHast We are pleased to announce a new set of tools to rapidly screen antibodies, Fab-pHast conjugates. The ATS pHAST product line provides the FASTEST results in quantitative testing of your antibody’s specific-binding and internalization. Fab-pHast contains a pH-dependent fluorescent reporter that increases intensity in acidic surroundings, such
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Anti-OX1R-SAP (Cat. #BETA-007) eliminates mouse, rat, and guinea pig cells expressing the orexin 1 receptor. All other cells are left untouched. Anti-OX2R-SAP (Cat. #BETA-008) eliminates rat cells expressing the orexin 2 receptor (OX2R). All other cells are left untouched. These two immunotoxins are being offered as part of our Beta Testing program. They have not
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ATS is pleased to re-release a product and kit specific for the Orexin 2 receptor (OX2R). The Orexin 1 and Orexin 2 receptors are found in the perifornical area/latero-posterior hypothalamus, and projections from this area cover much of the brain. These receptors have been implicated in various neurophysiological and neuropsychological disorders such as narcolepsy, insomnia,
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