Top Five Targeted Toxins #1. CTB-SAP (Cat. #IT-14) – targets cells expressing GM1 receptor #2 Mac-1-SAP (Cat. #IT-06) – targets cells expressing Mac-1 (CD11b ) receptor #3 Anti-CD103-SAP (Cat. #IT-50) – targets cells expressing CD103 #4. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase #5. mu p75-SAP (Cat. #IT-16) – targets cells expressing mouse […]
Top 20 Targeting Tools of 2021 Read More »
Q: We are re-examining some data collected using an immunotoxin not prepared by your company (VChAT-sap). Our results in vivo indicated that there were non-specific effects although the creators claimed it was specific. We ran a Western Blot and determined that about half the saporin was not bound to the antibody. This may have been
Cytotoxicity of Unbound Saporin Read More »
Kim S, Shukla RK, Kim E, Cressman SG, Yu H, Baek A, Choi H, Kim A, Sharma A, Wang Z, Huang CA, Reneau JC, Boyaka PN, Liyanage NPM, Kim S (2022) Comparison of CD3e antibody and CD3e-sZAP immunotoxin treatment in mice identifies szap as the main driver of vascular leakage. Biomedicines 10(6):1221. doi: 10.3390/biomedicines10061221 Objective:
Aptamers are small, synthetic, single-stranded nucleic acids that fold into unique secondary structures. Unlike peptides and monoclonal antibodies, they are essentially non-immunogenic even when administered in excess amounts. The publications below explain how biotinylated aptamers combined with Streptavidin-conjugated saporin (Streptavidin-ZAP) can be used to screen aptamers for their ability to internalize into a specific cell
Screening Aptamers as Targeting Agents to Deliver Payloads Read More »
Rizvanovic H, Pinheiro AD, Kim K, Thomas J (2019) Chlorotoxin conjugated with saporin reduces viability of ML-1 thyroid cancer cells in vitro. bioRxiv 885483. doi: 10.1101/2019.12.20.885483 Objective: To determine whether Chlorotoxin-conjugated Saporin (CTX-SAP) would inhibit the growth of aggressive thyroid cancer cell lines expressing MMP-2. Summary: This in vitro study demonstrated the efficacy of a
alpha-CGRP-streptavidin-saporin
This kit includes 25 ug CGRP-SAP Kit (BETA-011), 25 ug Blank-Streptavidin-SAP (IT-27B)
CGRP-SAP [BETA-011] Read More »
ACTH-streptavidin-saporin
This kit includes 25 ug ACTH-SAP Kit (BETA-021), 25 ug Blank-Streptavidin-SAP (IT-27B)
ACTH-SAP [BETA-021] Read More »
αMSH-streptavidin-saporin
This kit includes 25 ug αMSH-SAP Kit (BETA-022), 25 ug Blank-Streptavidin-SAP (IT-27B)
αMSH-SAP [BETA-022] Read More »
vasopressin-streptavidin-saporin
This kit includes 25 ug Vasopressin-SAP Kit (BETA-023), 25 ug Blank-Streptavidin-SAP (IT-27B)
Vasopressin-SAP [BETA-023] Read More »
a tool for eliminating cells that express murine PirB (paired immunoglobulin-like receptor B) and p75 receptor expressing cells; targeted via a 42 amino acid Amyloid Beta peptide and eliminated via saporin
This kit includes 25 ug Amyloid Beta 42-SAP Kit (BETA-032), 25 ug Blank-Streptavidin-SAP (IT-27B)
Amyloid Beta 42-SAP [BETA-032] Read More »