Vasoactive intestinal peptide (VIP) is a 28 amino acid neuropeptide important in heart contractility, vasodilation, the lowering of arterial blood pressure, and in relaxing various smooth muscle tissues. It is expressed in a number of areas, including the gut, pancreas, and hypothalamus. VIP is also involved in synchronization of the circadian timekeeping machinery. There are two known VIP receptors. VPAC1 is expressed in the central nervous system, liver, lung, intestine, and T-lymphocytes. VPAC2 is found in the central nervous system, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach. VIP-SAP could be used to study circadian rhythm, heart failure, and various aspects of the digestive system.
VIP-SAP eliminates cells expressing VIP receptors (VPAC1, VPAC2).
The following control is recommended for validating the specificity of the beta conjugate: Blank-Streptavidin-SAP (Cat. #IT-27B).
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.