Nociceptin (Orphanin FQ) is a 17-amino acid peptide widely distributed within the central and peripheral nervous system functioning as an endogenous agonist of the Nociceptin (NOP) receptor formerly known as the opioid receptor-like 1 receptor (ORL1). Nociceptin has been confirmed to play a role in a variety of physiological functions involving not only the CNS and PNS but non-neuronal systems as well. These functions include pain, gastrointestinal motility, locomotion, learning and memory, neurotransmitter and hormone release, renal function neuronal differentiation, sexual and reproductive behavior and anxiety.
Nociceptin-SAP eliminates nociceptin-receptor expressing cells. All other cells are left untouched. It is not suitable for retrograde transport.
The following control is recommended for validating the specificity of the beta conjugate: Blank-Streptavidin-SAP (Cat. #IT-27B).
This product is being offered as part of our Beta Testing program. It has saporin activity confirmed, peptide sequences published/confirmed, and/or antibody binding specificity published/confirmed. It has not been characterized or reported in scientific literature. The researcher who first publishes data* will receive a $500 credit for use on ATS products.
*Data subject to review by the scientific team at ATS. See complete details here.