Abstracts from Society for Neuroscience (SFN) San Diego, CA • November 3-7, 2007
Abstracts from Society for Neuroscience (SFN) San Diego, CA • November 3-7, 2007 Read More »
Contributed by Robert M. Caudle, Ph.D.University of Florida College of Dentistry, Gainesville, FL 32610 A substantial amount of work with Advanced Targeting Systems’ substance P/saporin conjugate (SP-SAP, Cat. #IT-07) has demonstrated that neurokinin-1 (NK1) receptor-expressing neurons in the spinal cord and brain stem are necessary for the full expression of central sensitization following a peripheral
What is the claustrum? The simple answer is that it’s a brain structure that lies under the insular and piriform cortices. What it does is rather unclear, but one hypothesis has drawn considerable attention. The claustrum contains projections to the entire cortex, and this may indicate that it plays an important role in brain function.
New Targets: The Claustrum Read More »
Anti-CD22 (UV22-2) Mouse Monoclonal This IgG1k antibody (Cat. #AB-36) recognizes the group A epitope of the human B-cell antigen, CD22. Clone UV22-2 reacts exclusively with cells of human B-cell lineage. The fluorescent conjugate mouse IgG-FITC (Cat. #FL-07) is available as a research tool to use with this and other mouse monoclonal antibodies. Anti-CD22-SAP Immunotoxin This
Targeting Tools: Targeting B-Cell Leukemias and Lymphomas Read More »
In 1997, SP-SAP (a chemical conjugate of Substance P and the ribosome-inactivating protein saporin) was created to eliminate Substance P receptor (SPR) neurons that propagate the signal for chronic pain. ATS has successfully completed preclinical studies, safety tests in animal models and a GLP toxicology study in rat, funded both internally and by the National
Targeted Therapy for Chronic Pain Read More »
In the January 26 issue of Science there was an article by Naqvi et al. about patients with brain damage to the insula losing their desire to smoke. A podcast interview with Dr. Bechara, one of the authors of the study, ended with him stating that there are a number of known receptors in the brain that should be
New Targets: Insula Receptors Read More »
ATS has added three new products to our fluorescent conjugates line. Alexa488-labeled affinity purified NGFr* (Cat. #AB-N01APFLA) FITC-labeled Goat Anti-Rat IgG (Cat. #FL-10) FITC-labeled Donkey Anti-Goat IgG (Cat. #FL-11) *(Cat. #AB-N01AP) These conjugates are excellent tools to verify specific binding to an antigen. By first incubating cells with the primary antibody, and then binding the
Targeting Tools: Fluorescent Conjugates Read More »
Goat-ZAP (Cat. #IT-36) is a new secondary conjugate of affinity-purified rabbit anti-goat IgG and the ribosome-inactivating protein, saporin. This product uses affinity-purified rabbit anti-goat IgG to “piggyback” onto YOUR primary goat antibody in order to evaluate the ability of your primary antibody to internalize. Once the conjugate is internalized, saporin breaks away from the targeting
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Substance P-Saporin (SP-SAP) is a drug candidate that eliminates the spinal cord neurons that send the chronic pain signal to the brain. SP-SAP has been tested in a variety of animal models and proven effective in permanently eliminating the perception of chronic pain. ATS has completed extensive preclinical studies, a GLP toxicology study, and a
SP-SAP Drug Development Update Read More »
Contributed by Jeffrey T. Potts, Ph.D., Department of Biomedical Science, College of Veterinary Medicine, Dalton Cardiovascular Research Center, Columbia, MO 65211 The nucleus tractus solitarii (NTS) receives afferent input from visceral, somatic and cardiopulmonary structures and is the first central site for the processing of these sensory autonomic signals. Modulation of sensory neurotransmission has been well