July Blast

Online orders only, enter JulyBlast to receive  2 vials of any size of 192-IgG-SAP (Cat. #IT-01)  for the price of 1.      This promotion is valid for the month of July.   Add 2 vials to your shopping cart;  1 vial is free when you enter the code JulyBlast during checkout.    This discount will be confirmed by […]

Targeting Stem Cells

Latest research using 192-IgG-SAP to eliminate p75-positive neurons. Nitric Oxide Donor Molsidomine Promotes Retrieval of Object Recognition Memory in a Model of Cognitive Deficit Induced by 192 IgG-Saporin. (2019). Behav Brain Res, 366 108-117. Hernández-Melesio MA, Alcaraz-Zubeldia M, Jiménez-Capdeville ME, Martínez-Lazcano JC, Santoyo-Pérez ME, Quevedo-Corona L, Gerónimo-Olvera C, Sánchez-Mendoza A, Ríos C, & Pérez-Severiano F. […]

Targeting Stem Cells

Stem cell research has great potential to understand, treat and cure diseases.  By watching stem cells mature into cells in bones, heart muscle, nerves, and other organs and tissue, researchers can determine how diseases and conditions develop.  Here are some recent publications that use ATS products to advance research involving stem cells. Figure Legend.  Non-genotoxic conditioning for hematopoietic stem cell transplantation […]

Targeting Glioblastoma

Glioblastoma, or glioblastoma multiforme (GBM), is a rare disease, with a global incidence of <10 per 100,000 people; the prognosis is very poor.  Here are a couple of recent studies testing targeted saporin therapies. Integrin α10, a Novel Therapeutic Target in Glioblastoma, Regulates Cell Migration, Proliferation, and Survival. Munksgaard Thorén M, Chmielarska Masoumi K, Krona C, […]

Q1 2019 Scientific Review

IT-01: 192-IgG-SAP     • Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease. LID – 10.1007/s00213-018-5150-y [doi]. Koshy Cherian A et al. (2019). Psychopharmacol (Berl), [Epub ahead of print]  Dose: Basal forebrain cholinergic neurons situated in the nucleus basalis and substantia innominata were targeted with […]

Targeting motor neuron disease

Motor neuron diseases are a group of progressive neurological disorders that destroy motor neurons, the cells that control essential voluntary muscle activity such as speaking, walking, breathing, and swallowing. When there are disruptions in the signals between the lowest motor neurons and the muscle, the muscles do not work properly; the muscles gradually weaken and […]

Call for Proposals

Advanced Targeting Systems and its Contract Service partner, CytoLogistics announce a Call For Proposals for research collaborations on: Receptor-mediated Delivery: New Targets Selected researchers will receive support for smaller scale or pilot research projects ($1,000 – $25,000) with the targeting tools and contract services needed for the identification and characterization of new cell-surface markers for […]

Targeting Tools: Top Twenty of 2018

Top Five Targeted Toxins 1. CTB-SAP (Cholera Toxin B-Saporin) (Cat. #IT-14) – targets cells expressing GM1 receptor 2. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase (DBH) 3. 192-IgG-SAP (192-Saporin) (Cat. #IT-01) – targets cells expressing rat p75NTR 4. Anti-ChAT-SAP (Cat. #IT-42) – targets cells expressing choline acetyltransferase 5. Nppb-SAP (Neuropeptide natriuretic polypeptide […]

Targeting Topics: 2018 Scientific References

TARGETED TOXINS – Targeting agent attached to Saporin IT-01 192-IgG-SAPNeuropharmacology of attention. Burk JA, et al. Eur J Pharmacol 835: 162-168, 2018 Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods. Cho JS, et al. Yonsei Med J 59: (3):406-415, 2018.Intracerebroventricular Administration of […]