In 1997, Melanopsin was discovered by Dr. Ignacio Provencio as a novel opsin in the melanophores (light-sensitive skin cells) of the African clawed frog.[1]  Provencio and colleagues then found in 2000 that melanopsin is also present in mouse retina, specifically in ganglion cells, and that it mediates non-visual photoreceptive tasks.[2]   Melanopsin has since been found to be […]

Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model. Fujita M, Fukuda T, Sato Y, Takasusuki T, & Tanaka M. (2018). Korean J Pain, 31 (1):10-15. Applications include immunohistochemistry, flow cytometry, immunoblotting, and ELISA. The objective in the study published by Fujita et al. […]

Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Dysfuntion of cholinergic neurons underlies aspects of clinical symptoms found in neurological and psychiatric disorders such as Alzheimer’s disease, Down and […]

Li J, Rao D, & Gibbs RB. Effects of Cholinergic Lesions and Cholinesterase Inhibitors on Aromatase and Estrogen Receptor Expression in Different Regions of the Rat Brain. (2018). Neuroscience, 384 203-213. Dose:  Rats received intraseptal injections of 2.0 ml (0.2 mg/ml) or icv injections of 0.4 mcg.  Lesions resulted in loss of ChAT-positive cells in the septum, and […]

Targeting Results from FENS (The Federation of European Neuroscience Societies) will be presented at this year’s meeting in Berlin. Advanced Targeting Systems congratulates the researchers on their work and looks forward to viewing the posters and interacting with scientists from around the world at this year’s meeting in Berlin. Come visit us at Booth 165 […]