AAIC 2022

Join us in San Diego and online for AAIC 2022, where the world’s leading basic scientists, clinical researchers, early career investigators, clinicians and the care research community will share breaking research discoveries that will lead to methods of prevention and treatment and improvements in diagnosis for Alzheimer’s disease. Molecular Surgery definition: Specifically remove cells based …

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A Brief History of Saporin and its Contributions to Neuroscience

ABSTRACT When investigating the origins of targeted toxins (a drug, therapy, or scientific tool directed to unique extracellular target), and appropriate place to begin is with the Nobel Prize-winning work of Paul Ehrlich and his concept of the “magic bullet.” Over 100 years later, the use of targeted toxins to perform molecular neurosurgery has become …

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FENS 2022

Join us at Europe’s largest international neuroscience conference, covering all domains in modern brain research from basic to translational research Molecular Surgery definition: Specifically remove cells based on a unique cell surface marker; useful in both in vitro (e.g., antibody screening) and in vivo (e.g., ‘knock out’ models, functionomics) applications. Visit Booth 48, July 10-13 …

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EACR 2022

EACR 2022 Congress – Innovative Cancer Science: Translating Biology to Medicine 20-23 June 2022, Seville, Spain Molecular Surgery definition: Specifically remove cells based on a unique cell surface marker; useful in both in vitro (e.g., antibody screening) and in vivo (e.g., ‘knock out’ models, functionomics) applications. Visit Booth 12, June 20-23 and find out how …

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Immunology 2022

Molecular Surgery definition: Specifically remove cells based on a unique cell surface marker; useful in both in vitro (e.g., antibody screening) and in vivo (e.g., ‘knock out’ models, functionomics) applications. Visit Booth 339 May 7-9 and find out how you can use Molecular Surgery to accelerate your Immunology research!

Targeting Trends 2021 Review

Read the complete 2021 Review. Targeted Ablation with IB4-SAP: Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis Scientific References Top 20 Targeting Tools

Top 20 Targeting Tools of 2021

Top Five Targeted Toxins #1. CTB-SAP  (Cat. #IT-14) – targets cells expressing GM1 receptor #2 Mac-1-SAP (Cat. #IT-06) – targets cells expressing Mac-1 (CD11b ) receptor #3 Anti-CD103-SAP (Cat. #IT-50) – targets cells expressing CD103 #4. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase  #5. mu p75-SAP (Cat. #IT-16) – targets cells expressing mouse …

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Targeted Ablation with IB4-SAP

Selective ablation of IB4+ primary afferent neurons reduces mechanical and cold hyperalgesia in an EAE mouse model of multiple sclerosis Kayla L. Nguyen1, Sydney R. Lamerand1, Ronit P. Deshpande1, Bradley K. Taylor1,2 1Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA2Center for Neuroscience at the University of Pittsburgh, Pittsburgh, PA …

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