Strategies to overcome 5-FU resistance in cancer

Congratulations to the Selbo laboratory for their recent publication using Anti-CD105-SAP. This targeted toxin was previously part of the BETA program. As first to publish using this product, Selbo’s group receives a $500 product credit and applause for their great work. 5-Fu Resistant Emt-Like Pancreatic Cancer Cells Are Hypersensitive to Photochemical Internalization of the Novel […]

February Promotion

Purchase any size:    Anti-CD105-SAP  (Cat. #IT-80; Cat. #KIT-80)  and get a second one free on any online order.   Enter Code FebruaryBlast. *Not good with any other promotion.       Offer expires 28 February 2018.  

Screening Aptamers as Targeting Agents to Deliver Payloads

Aptamers are small, synthetic, single-stranded nucleic acids that fold into unique secondary structures. Unlike peptides and monoclonal antibodies, they are essentially non-immunogenic even when administered in excess amounts. The publications below explain how biotinylated aptamers combined with Streptavidin-conjugated saporin (Streptavidin-ZAP) can be used to screen aptamers for their ability to internalize into a specific cell […]

Streptavidin-ZAP evaluates antibodies for targeted tumor treatment

Characterization of the First Fully Human Anti-Tem1 Scfv in Models of Solid Tumor Imaging and Immunotoxin-Based Therapy. Yuan, X, Yang, M, Chen, X, et al. (2018). Cancer Immunol Immunother 2018/01/10. Streptavidin-ZAP (Cat. #IT-27) Objective: ScFv78 was conjugated with the ribosome-inactivating protein saporin (Streptavidin-ZAP) to evaluate whether scFv78 may be used as a vehicle for theTEM1-targeted […]

New publications: Melanopsin, Serotonin, Streptavidin

2018 starts off with 3 new publications using ATS products. Check out these articles and take advantage of special promotions for each of the products used. Melanopsin Retinal Ganglion Cells Are Not Labeled in Thy-1yfp-16 Transgenic Mice. Grillo, SL, & Stella, SL, Jr. (2018). Neuroreport, 29 (2):118-122. 2017/12/19. Objective: to determine whether mRGCs are labeled […]

10% Off PLUS Free Shipping!

Extended through February!!! Order Online and receive 10% off your order of $100 or more PLUS free shipping!* Use promo code:  FreeShip Promotions on targeting tools are updated regularly. Check back frequently or join our mailing list. Click on My Account and register now.    Maximum value of $80 for shipping; additional charges may be incurred […]

snowman

11 Shopping Days Left in 2017

ATS will only be shipping on 11 more business days this year. Place your order now to take advantage of our current promotions and stock up your lab for work to be done between 25 December and 3 January.

Guillemin

Roger Guillemin honored by Université de Montréal

On December 5, 2017, Dr. Roger Guillemin was  honored by Université de Montréal by the naming of its assembly hall after him.  The honorary plaque will be installed at the entrance to the University Assembly hall, now re-named to mark the 40th anniversary of the French-born physician’s Nobel Prize for medicine. Salle Roger-Guillemin Born on […]

IB4-SAP to study mechanical hyperalgesia

To determine which subtype of nociceptor, peptidergic or non-peptidergic, is involved in the mechanical hyperalgesia induced by LMWH (low molecular weight hyaluronan), rats were pretreated with neurotoxins previously shown to selectively deplete these two types of sensory neurons:  Isolectin B4 (IB4)-saporin (SAP), which acts on IB4-positive, non-peptidergic neurons (Cat. #IT-10 IB4-SAP), and substance P-saporin (Cat. […]