Stop by our virtual booth at the SFN Global Connectome, January 11-13. This digital neuroscience event is open to all neuroscientists and is designed to facilitate scientific exchange across the globe and across the field, providing scientists at all career stages with opportunities to learn, collaborate, and connect. Get your questions answered and find out …
SFN 2021 Virtual Survey & Drawing
“Saporin… the scalpel used in Molecular Neurosurgery” Complete this survey to be entered into a drawing to win this Saporin Hoodie!
New Publications using Saporin conjugates
Cat. #IT-01 192-IgG-SAP Lesions of the nucleus basalis magnocellularis (Meynert) induce enhanced somatosensory responses and tactile hypersensitivity in rats. Dezawa S, Nagasaka K, Watanabe Y, & Takashima I. (2020). Exp Neurol, 335 113493. 2020/10/05. Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits. Moschonas EH, Leary JB, …
World Alzheimer’s Month – Latest publications
Cat. #IT-01 192-IgG-SAP Long-term potentiation in the hippocampal CA3 to CA1 synapses may be induced in vivo by activation of septal cholinergic inputs. Dobryakova, Y. V., M. Y. Stepanichev, V. A. Markevich and A. P. Bolshakov (2020). Int J Neurosci: 1-9. Intracerebroventricular Administration of 192IgG-Saporin Alters the State of Microglia in the Neocortex. Volobueva, M. N., Y. …
Featured Saporin Conjugates
Antibody-Saporin Conjugates (able to be retrogradely transported) Saporin Conjugate(s) Molecular Target Cell Subpopulation Killed References 192-IgG-SAP(192-Saporin) Nerve growth factorreceptor (NGFR),p75NTR Rat cholinergic forebrainneuronsUpper cervical ganglion Cat. #IT-01 Anti-ChAT-SAP(ChAT-SAP) Cholineacetyltransferase(ChAT) Cholinergic interneurons ofdorsal striatum Cat. #IT-42 Anti-DAT-SAP(DAT-SAP) Dopamine Transporter(DAT) Dopaminergic neuronsParkinson’s disease Model Cat. #IT-25 Anti-DBH-SAP(DSAP) Dopamine betahydroxylase (DBH) Locus coeruleus/subcoeruleusAlzheimer’s disease Model Cat. #IT-03 Anti-GAT1-SAP(GAT1-SAP) …
Targeting Trends 2019 Review
ATS and Cytologistics move to Carlsbad Targeted Ablation with SSP-SAP Scientific References Poster of the Year Custom Services with Cytologistics Top 20 Targeting Tools Text editor
Targeted ablation with SSP-SAP
Targeted hippocampal GABA neuron ablation produces hippocampal sclerosis, epilepsy, and dissociable effects on the Morris Water Maze and Object-Place Paired Association tasks by Argyle V. Bumanglag1, Leah M. Truckenbrod1, Eugene Chun2, Abbi R. Hernandez1, Quinten P. Federico1, Andrew P. Maurer1, Robert S. Sloviter3,4, Sara N. Burke1 1Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, …
2019 Scientific References
Targeted Toxins Secondary Conjugates Selected Antibodies pHast Conjugates Custom Conjugates Targeted Toxins: Targeting agent attached to Saporin IT-01 192-IgG-SAP Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson’s disease (2019) Koshy Cherian A, et al. Psychopharmacol (Berl) Basal forebrain chemogenetic inhibition disrupts the superior complex movement …
Top 20 Targeting Tools of 2019
Top Five Targeted Toxins #1. CTB-SAP (Cat. #IT-14) – targets cells expressing GM1 receptor #2. 192-IgG-SAP (Cat. #IT-01) – targets cells expressing rat p75NTR #3. Anti-DBH-SAP (Cat. #IT-03) – targets cells expressing rat dopamine beta-hydroxylase #4. IB4-SAP (Cat. #IT-10) – targets cells expressing alpha-D-galactopyranoside residues #5. CCK-SAP (Cat. #IT-06) – targets cells expressing sulfonated Cholecystokinin Top Five …
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