Award winner for animal model of temporal lobe epilepsy

Congratulations to Dr. Argyle Bumanglag and the team at University of Florida for the important work they presented using SSP-SAP to create an animal model of temporal lobe epilepsy. Injections of SSP-SAP into the hippocampus of a rat causes acute hippocampal injury, permanent dentate granule cell-onset epilepsy, and hippocampal sclerosis that closely resembles the selective …

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Abstracts from Society for Neuroscience (SFN) Symposium October 19-23, 2019 – Chicago, IL

048.01 / F11 – Increased transplantation efficacy of mesenchymal stem cell by focused ultrasound and improvement of the spatial memory in the 192 IgG-saporin rat model *J. LEE1,2, Y. SEO1,2, J. SHIN1,2, C. KONG1, Y. NA3, W. CHANG1, J. CHANG1,2; featuring IT-01 192-IgG-SAP 052.10 / H30 – Nociceptors expressing TRPV1 and trigeminal nucleus neurons expressing …

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SfN Poster of the Year Contenders

The Society for Neuroscience meeting is just around the corner.  Come visit us in Chicago  – October 19-23, Booth #763.  Here is a list of the posters competing for the Annual Post of the Year Award using ATS products. (click to zoom) Saturday, October 19 Sunday, October 20 Monday, October 21 Tuesday, October 22 Wednesday, …

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Fab-pHast products

Fab-pHast products bind to your primary antibody via a secondary antibody or Streptavidin cross-linked to a pH-dependent fluorescent reporter.  This fluorescent reporter increases intensity as the pH of its surroundings becomes more acidic, as evident when exposed to the environment inside a cell. SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked …

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Orexin-SAP Model of Sleep Disorders

Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-Yloxy)Phenyl]-2-(Morpholin-4-Yl)Acetamide Dihydrochloride (Suvn-G3031): A Novel, Potent, Selective, and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity. (2019). J Med Chem, 62 (3):1203-1217. Nirogi R, Shinde A, Mohammed AR, Badange RK, Reballi V, Bandyala TR, Saraf SK, Bojja K, Manchineella S, Achanta PK, Kandukuri KK, Subramanian R, Benade V, …

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Leptin responsiveness in mediating weight loss

Leptin receptor-expressing neurons in the ventromedial nucleus of the hypothalamus contribute to weight loss caused by fourth ventricle leptin infusions. (2019). Am J Physiol Endocrinol Metab  PMID: 31361549Seamon M, Ahn W, Li A-J, Ritter S, & Harris RBS. IT-47:  Leptin-SAP Objective: To test the importance of VMH leptin responsiveness in mediating weight loss caused by fourth ventricle …

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Neuroprotective Effects of Exercise

Neuroprotective Effects of Exercise on the Morphology of Somatic Motoneurons Following the Death of Neighboring Motoneurons. (2019). Chew C, & Sengelaub DR. Neurorehabil Neural Repair, epub ahead of print 1545968319860485.  IT-14:  CTB-SAP Objective:  To explore whether exercise shows the same neuroprotective effect on induced dendritic atrophy as that seen with androgen treatment.Summary:  Exercise following neural …

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Latest Itch research using Targeted Toxins

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch. (2019). Cell Reports, 28 (3):625-639.e626. Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, Eva C, & Goulding M. Objective:  To determine the central pathway for mechanical itch.Summary:  NPY-Y1 signaling regulates the transmission of innocuous tactile information by establishing biologically relevant thresholds for …

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