Striatum, dopamine neurotransmission, Dermorphin, Huntington Disease

Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway. Objective:  To increase knowledge in the role of the striosomal projection onto the dopamine neurons of the SNc and its impact on the nigrostriatal dopamine pathway. Summary:  Results highlight the key function of the striosomes for maintenance of the striatal dopamine tone and […]

Breathing, Parkinson’s Disease and Targeting Orexin Receptors

Orexin-B-SAP (Cat. #IT-20): a tool for eliminating cells that express the orexin-2 receptor; targeted via orexin-B peptide, eliminated via saporin. Orexinergic Neurons Are Involved in the Chemosensory Control of Breathing During the Dark Phase in a Parkinson’s Disease Model. Oliveira LM, Falquetto B, Moreira TS, & Takakura AC (2018) Exper Neurol, 309:107-118. Objective:  To determine […]

Reliable Antibodies

3. Fujita, et al. Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model (2018). Korean J Pain.  AB-N33AP; Anti-NK-1 receptor. 4. SGrillo, et al. Melanopsin retinal ganglion cells are not labeled in Thy-1YFP-16 transgenic mice (2018). Neuroreport.  AB-N39: Anti-Melanopsin. 5. Hamano, et al. Extracellular […]

Mac-1 rat discontinued

The following products have been discontinued. Please check out IT-06 Mac-1-SAP to eliminate Mac-1 positive (CD11b positive) cells in mouse/human. Discontinued: AB-N06, IT-33, KIT-33

See what it’s all about: Melanopsin, retinal cells

In 1997, Melanopsin was discovered by Dr. Ignacio Provencio as a novel opsin in the melanophores (light-sensitive skin cells) of the African clawed frog.[1]  Provencio and colleagues then found in 2000 that melanopsin is also present in mouse retina, specifically in ganglion cells, and that it mediates non-visual photoreceptive tasks.[2]   Melanopsin has since been found to be […]

Antibody to the NK-1 Receptor and Postoperative Pain

Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model. Fujita M, Fukuda T, Sato Y, Takasusuki T, & Tanaka M. (2018). Korean J Pain, 31 (1):10-15. Applications include immunohistochemistry, flow cytometry, immunoblotting, and ELISA. The objective in the study published by Fujita et al. […]

Targeting ChAT – An innovative tool to Study Alzheimer’s Disease

Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Dysfuntion of cholinergic neurons underlies aspects of clinical symptoms found in neurological and psychiatric disorders such as Alzheimer’s disease, Down and […]

Targeting Cholinergic Neurons

Li J, Rao D, & Gibbs RB. Effects of Cholinergic Lesions and Cholinesterase Inhibitors on Aromatase and Estrogen Receptor Expression in Different Regions of the Rat Brain. (2018). Neuroscience, 384 203-213. Dose:  Rats received intraseptal injections of 2.0 ml (0.2 mg/ml) or icv injections of 0.4 mcg.  Lesions resulted in loss of ChAT-positive cells in the septum, and […]

Abstracts from The Federation of European Neuroscience Societies (FENS) 2018

F055 Behavioral effects of immunotoxin 192IgG-saporin depends on the type of its administration to rats. Yulia Dobryakova, Alexey Bolshakov, Maria Zaichenko, Mikhail Stepanichev, Vlaimir Markevich featuring IT-01 192-IgG-SAP (Sunday 2:00pm-5:30pm) It is known that degeneration of cholinergic neurons is one of key events during development of Alzheimer’s disease. We used immunotoxin 192IgG-saporin, a conjugate of antibody to […]

The latest neuroscience news from Europe

Targeting Results from FENS (The Federation of European Neuroscience Societies) will be presented at this year’s meeting in Berlin. Advanced Targeting Systems congratulates the researchers on their work and looks forward to viewing the posters and interacting with scientists from around the world at this year’s meeting in Berlin. Come visit us at Booth 165 […]