Contributed by Ai-Jun Li, Qing Wang, Thu T. Dinh and Sue Ritter Programs in Neuroscience, Washington State University, Pullman, Washington 99164-6520, USA Leptin is a fat tissue-derived hormone with widespread actions in brain and peripheral tissues. Leptin’s actions are mediated by the long isoform of the leptin receptor, OB-Rb, which has a lengthy intracellular region […]

Contributed by Zhou-Feng Chen, Yang-Gang Sun, Zhong-Qiu Zhao, Xiu-Li Meng, Jun Yin, Xian-Yu Liu; Washington University Pain Center School of Medicine, Dept of Anesthesiology, St. Louis, MO 63141 Unlike pain, itch sensation evokes scratching response instead of withdrawal behavior. However, itch and pain sensations share many similarities. Like chronic pain, chronic itch is a major clinical

ATS has been awarded a Phase I SBIR grant to develop a new line of products. Dr. Douglas Lappi is the Principal Investigator and Brian Russell is the Lead Scientist on the project. Molecules targeted towards cell surface markers have been used for years to identify specific cell types. It has been demonstrated over the

Contributed by Maria Montero (a), Berta Gonzalez (b), Jens Zimmer (a)(a) Anatomy and Neurobiology, University of Southern Denmark, Denmark(b) Histology Unit, Autonomous University of Barcelona, Spain Microglial cells contribute about 12% of the cells in the brain, acting as “biosensors” for homeostatic regulation in normal and pathological conditions.[3,13] Resting microglial cells in the adult brain