Targeting Tools: Anti-Basigin

This mouse monoclonal antibody (Cat. #AB-42; Clone P2C2) recognizes human Basigin. The antibody is purified by ammonium sulfate precipitation on conditioned medium and then further purified through Protein-A. The antibody is routinely tested by flow cytometry. The immunoglobulin superfamily protein basigin (EMMPRIN/CD147) is a cell surface glycoprotein expressed by tumor cells that stimulates matrix metalloproteinase (MMP) and vascular endothelial growth factor (VEGF). With basigin’s ability to stimulate the expression of molecules that participate in tissue remodeling and angiogenesis, it may prove to be a potential target for the development of methods to inhibit metastasis.

A: Anti-basigin recognizes native glycosylated basigin in HeLa cell lysate. B: The basigin monoclonal antibody immunoprecipitates glycosylated basigin proteins from a variety of human cell lines such as cervical carcinomas (C4- I/C4-II), uterine epithelials (HES), and uterine fibroblasts (HESC).
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