Basic fibroblast growth factor (FGF-2) is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration […]
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by Leonardo R. Ancheta and Douglas A. Lappi, American Association of Cancer Research abstract #5218 Basigin-2 (EMMPRIN) is a marker for prognosis of several tumor types. With the identification of the internalization of basigin-2 in response to antibody binding, we now further explore the possibility of its use as a dynamic portal of entry for
Contributed by L.S. Sorkin, J.-I. Choi, and F.J. Koehrn, Univ. California San Diego, La Jolla, CA Paw inflammation with carrageenan elicits phosphorylation of Akt in spinal cord neurons with an unusual time course (Choi et al., 2010). Activation of Akt is seen first in neurons of the superficial dorsal horn and in α-motor neurons, followed
Anti-dopamine beta-hydroxylase-saporin (anti-DBH-SAP, Cat. #IT-03) is a highly specific noradrenergic lesioning agent. It specifically targets rat cells that express dopamine beta-hydroxylase and is also reported to react with mouse protein.1 This vesicular enzyme is exposed to the exterior milieu upon release of noradrenaline and thus allows these cells to be targeted with saporin. The specificity
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Contributed by Lisa E. Goehler and Ronald P.A. Gaykema Center for the Study of Complementary and Alternative Therapies, University of Virginia School of Nursing, Charlottesville, VA 22908 Fatigue, experienced as reduced motivation and motor activity, is common in acute and chronic disease, including heart disease, cancer and cancer chemotherapy. Fatigue is part of a constellation
Read the 2010 Newsletters and recent scientific references 2010, issue 1: 2010, issue 2: 2010, issue 3: 2010, issue 4:
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Awarded by ATS at Society for Neuroscience (SFN) November 14-17, 2010 • San Diego, CA 331.5/B19 Functional cholinergic neurons from human embryonic stem cellsY Liu, R Krencik, H Liu, L Ma, X Zhang, S-C Zhangfeaturing IT-16 mu p75-SAP (Poster; Monday, Nov. 15, 8:00 am – 9:00 am) Basal forebrain cholinergic neurons play a critical role
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GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving g-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy,
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Advanced Targeting Systems, the company that pioneered the targeting of specific cell types to manipulate them for the treatment of diseases and for research into the function of biological systems, has been awarded $3 million from the National Cancer Institute (NCI). Representatives from the NCI stated that the Advanced Targeting Systems proposal was ranked #1
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