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Effects of mice EGF-responsive neural stem cells grafts and fetal septal cells grafts implanted into the dorsal hippocampus of rats after immunotoxic denervation
Jeltsch H, Aloy E, Schimchowitsch S, Caillard S, Mohier E Cassel JC (2002) Effects of mice EGF-responsive neural stem cells grafts and fetal septal cells grafts implanted into the dorsal hippocampus of rats after immunotoxic denervation. FENS 2002 Abstracts 141.13. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Selective lesioning of the developing cholinergic and noradrenergic systems: Anatomical, neurochemical and functional effects
Leanza G, Cataudella T (2002) Selective lesioning of the developing cholinergic and noradrenergic systems: Anatomical, neurochemical and functional effects. FENS 2002 Abstracts 151.12. Federation of European Neuroscience Societies, Paris, France.
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Selective neonatal lesions of the basal forebrain cholinergic neurons impair memory of socially-transmitted food preferences in adult rats
Ricceri L, Moles A, Scattoni ML, Calamandrei G (2002) Selective neonatal lesions of the basal forebrain cholinergic neurons impair memory of socially-transmitted food preferences in adult rats. FENS 2002 Abstracts 209.4. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm.
Johnson DA, Zambon NJ, Gibbs RB (2002) Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm. Brain Res 943(1):132-141. doi: 10.1016/s0006-8993(02)02623-9
Summary: The authors investigated the effects of selective cholinergic depletion in the medial septum on a spatial memory (DMP) task. Direct infusion of 0.22 or 1.0 µg 192-Saporin (Cat. #IT-01) produced a near complete depletion of cholinesterase-positive neurons for either dose. The DMP task provides a sensitive behavioral assay for deficits in cholinergic projections.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain: A neurochemical and behavioral study.
Lehmann O, Jeltsch H, Lazarus C, Tritschler L, Bertrand F, Cassel JC (2002) Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain: A neurochemical and behavioral study. Pharmacol Biochem Behav 72(4):899-912. doi: 10.1016/s0091-3057(02)00752-9
Summary: Female rats treated with both 192-Saporin (Cat #IT-01) and 5,7-DHT exhibited working memory impairments that were not seen with either treatment alone. For this paper, male rats were treated with 5,7-DHT and 1 µg per ventricle of 192-Saporin. While each compound produced a unique combination of effects, cognitive performance was only affected by treatment with both agents. These data indicate that interaction between the cholinergic and serotonergic mechanisms plays a role in cognitive functions for both sexes.
Usage: Injections of 1 µg per ventricle of 192-Saporin (Cat. #IT-01).
Related Products: 192-IgG-SAP (Cat. #IT-01)
5,7-DHT-induced hippocampal 5-HT depletion attenuates behavioural deficits produced by 192 IgG-saporin lesions of septal cholinergic neurons in the rat.
Lehmann O, Bertrand F, Jeltsch H, Morer M, Lazarus C, Will B, Cassel JC (2002) 5,7-DHT-induced hippocampal 5-HT depletion attenuates behavioural deficits produced by 192 IgG-saporin lesions of septal cholinergic neurons in the rat. Eur J Neurosci 15(12):1991-2006. doi: 10.1046/j.1460-9568.2002.02037.x
Summary: Although past data has shown that the cholinergic system of the basal forebrain is intrinsic to learning and memory, more recent data suggests that other neurotransmitter systems are also involved, perhaps serving modulatory functions. The authors used 5,7-DHT injections alone or with intraseptal 192-Saporin (Cat #IT-01, 0.4 µg/side) injections in rats. The results demonstrate that serotonergic denervation of the hippocampus attenuates deficits produced by a cholinergic denervation of the septal region of the basal forebrain.
Usage: The authors used 192-Saporin, 0.4 µg/side intraseptal (Cat. #IT-01).
Related Products: 192-IgG-SAP (Cat. #IT-01)
Unilateral lesions of the cholinergic Basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys.
Easton A, Ridley RM, Baker HF, Gaffan D (2002) Unilateral lesions of the cholinergic Basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys. Cereb Cortex 12(7):729-736. doi: 10.1093/cercor/12.7.729
Summary: The authors used a combination of basal forebrain lesioning using ME20.4-SAP (Cat. #IT-15) and surgery to isolate the inferior temporal cortex and medial temporal cortex from cholinergic afferents in rhesus monkeys. Testing of the treated animals demonstrated severe impairments in learning visual scenes and object-reward associations.
Related Products: ME20.4-SAP (Cat. #IT-15)
Chronic pain and medullary descending facilitation
Porreca F, Ossipov MH, Gebhart GF (2002) Chronic pain and medullary descending facilitation. Trends Neurosci 25(6):319-325. doi: 10.1016/s0166-2236(02)02157-4
Objective: To examine the likelihood that sustained activation of descending modulatory pathways that facilitate pain transmission could underlie some states of chronic pain.
Summary: Rats treated with Dermorphin-SAP, either before or after spinal nerve ligation injury, did not display neuropathic pain behaviors, although normal nociceptive responses were intact.
Usage: Rostroventromedial medulla (RVM) injected with Dermorphin-SAP.
Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12)
See Also:
Selective immunolesioning of the basal forebrain cholinergic neurons in rats: effect on attention using the 5-choice serial reaction time task.
Risbrough V, Bontempi B, Menzaghi F (2002) Selective immunolesioning of the basal forebrain cholinergic neurons in rats: effect on attention using the 5-choice serial reaction time task. Psychopharmacology 164:71-81. doi: 10.1007/s00213-002-1170-7
Summary: The authors used 0.067 µg injections of 192-Saporin (Cat. #IT-01) into the nucleus basalis magnocellularis to investigate attentional performance in rats. The treated animals exhibited a very specific subset of attentional deficits, many centered around increased difficulty completing tasks in the presence of distractions.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain.
Burgess SE, Gardell LR, Ossipov MH, Malan Jr TP, Vanderah TW, Lai J, Porreca F (2002) Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. J Neurosci 22(12):5129-5136. doi: 10.1523/JNEUROSCI.22-12-05129.2002
Summary: Various indications, such as declining afferent discharge over time, suggest that the mechanisms involved in persistent neuropathic pain are different than those that initiate the pain. The authors have previously shown that cells expressing the mu-opioid receptor are involved in the descending pain pathway. In this work, the authors lesioned the rostral ventromedial medulla (RVM) in rats using 1.5 pmol in 0.5 µl of dermorphin-SAP (Cat. #IT-12) administered to each side of the RVM. Measurements of pain-related behavior show that mu-opioid receptor-expressing cells in the RVM are involved in the maintenance of heightened sensitivity to stimuli seen in neuropathic pain.
Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12)