targeted-toxins

Yezierski RP, Yu C, Lappi DA, Mantyh PW, Wiley RG (2002) Role of lamina I neurons expressing the substance P receptor in the prevention and treatment of a spontaneous pain-like behavior following excitotoxic spinal cord injury (SCI). IASP 2002 Abstracts International Association for the Study of Pain, San Diego, CA.

Related Products: SSP-SAP (Cat. #IT-11)

Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH (2002) Plasticity of wide dynamic range neurones following site-selective ablation of NK-1 receptor expressing lamina I neurones in rat spinal cord. IASP 2002 Abstracts International Association for the Study of Pain, San Diego, CA.

Related Products: SP-SAP (Cat. #IT-07)

Lehmann O, Grottick AJ, Cassel JC, Higgins GA (2002) Differential contribution of the cholinergic basal nuclei to attention and spatial memory in the rat. FENS 2002 Abstracts 008.13. Federation of European Neuroscience Societies, Paris, France.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Yamazaki Y, Hamaue N, Sumikawa K (2002) Nicotine compensates for the loss of cholinergic function to enhance long-term potentiation induction. Brain Res 946(1):148-152. doi: 10.1016/s0006-8993(02)02935-9 PMID: 12133604

Objective: Investigate the mechanisms of how cholinergic lesions impair the induction of long-term potentiation (LTP) and how nicotine can reverse the effects.

Summary: LTP in the hippocampal CA1 region is involved in learning and memory and its induction depends on the activation of N-methyl-D-aspartate receptors (NMDARs). Nicotine is shown to reverse memory deficits caused by lesioning of the cholinergic system, but the mechanism for this observation is unknown. The authors use 192-IgG-SAP to induce cholinergic lesioning, which impairs LTP induction. The authors suggest the compensatory action of nicotine is a via enhancement of NMDAR responses mediated by nicotine-induced disinhibition of pyramidal cells.

Usage: 2 ug of 192-IgG-Saporin (Cat. IT-01) were injected into the lateral ventricle of rats.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Beaule C, Amir S (2002) Effect of 192 IgG-saporin on circadian activity rhythms, expression of P75 neurotrophin receptors, calbindin-D28K, and light-induced Fos in the suprachiasmatic nucleus in rats. Exp Neurol 176(2):377-389. doi: 10.1006/exnr.2002.7969

Summary: The authors used bilateral icv injections of 200 ng of 192-Saporin (Cat. #IT-01) to investigate the contribution of p75NTR-expressing neurons to the determination of a circadian rhythm. The data show that p75NTR-expressing neurons are not essential for this process.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Hyde LA, Crnic LS (2002) Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer’s disease. Brain Res 945:26-30. doi: 10.1016/s0006-8993(02)02500-3 PMID: 12113948

Summary: The authors hypothesized that a mouse model for Down syndrome may show some of the same cognitive deficits exhibited by rats lesioned with 192-Saporin (Cat. #IT-01), which eliminates cholinergic cells in the basal forebrain. The results suggest that in this Down syndrome model, cell loss has a much greater cognitive effect if it happens early in development as opposed to in adulthood.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Simons CT, Gogineni AG, Iodi Carstens M, Carstens E (2002) Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors. Brain Res 945:139-143. doi: 10.1016/s0006-8993(02)02913-x

Summary: Capsaicin-induced irritation of the dorsal anterior tongue is mediated by nociceptors expressing VR-1 receptors. The role of NK-1 receptor-expressing neurons during the ingestion of capsaicin was examined by injecting 20 µl of 2.27 µM SP-SAP (Cat. #IT-07) into the cisterna magna of rats. Lesioned rats consumed significantly more water containing high concentrations of capsaicin than control animals.

Related Products: SP-SAP (Cat. #IT-07)

Brandner C (2002) Impairment and restoration of spatial abilities following 192 IgG-saporin or quisqualic acid lesions of the median septum in rats. FENS 2002 Abstracts 210.3. Federation of European Neuroscience Societies, Paris, France.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Ramirez MJ, Garcia-Alloza M, Lasheras B (2002) Short and long term-effects on the serotonergic system of a selective cholinergic lesion in rats. FENS 2002 Abstracts 010.16. Federation of European Neuroscience Societies, Paris, France.

Related Products: 192-IgG-SAP (Cat. #IT-01)

Lappi D, Kohls M, Majer K, Russell B, Blakely R Richerson G (2002) Targeting serotonin re-uptake transporter (SERT) -expressing cells with a monoclonal antibody to an epitope from the extracellular domain of SERT: Results with a saporin conjugate. FENS 2002 Abstracts 049.7. Federation of European Neuroscience Societies, Paris, France. PMID: 0

Related Products: Antibody to Serotonin Transporter (SERT, Cat. #AB-N09), Anti-SERT-SAP (Cat. #IT-23)