Lehmann O, Jeltsch H, Lazarus C, Tritschler L, Bertrand F, Cassel JC (2002) Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain: A neurochemical and behavioral study. Pharmacol Biochem Behav 72(4):899-912. doi: 10.1016/s0091-3057(02)00752-9
Summary: Female rats treated with both 192-Saporin (Cat #IT-01) and 5,7-DHT exhibited working memory impairments that were not seen with either treatment alone. For this paper, male rats were treated with 5,7-DHT and 1 µg per ventricle of 192-Saporin. While each compound produced a unique combination of effects, cognitive performance was only affected by treatment with both agents. These data indicate that interaction between the cholinergic and serotonergic mechanisms plays a role in cognitive functions for both sexes.
Usage: Injections of 1 µg per ventricle of 192-Saporin (Cat. #IT-01).
Related Products: 192-IgG-SAP (Cat. #IT-01)