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Identification of a potential ejaculation generator in the spinal cord.
Truitt WA, Coolen LM (2002) Identification of a potential ejaculation generator in the spinal cord. Science 297(5586):1566-1569. doi: 10.1126/science.1073885
Summary: The authors lesioned a specific population of rat spinothalamic neurons using 6-8 injections of 4 ng SSP-SAP (Cat. #IT-11). Whereas the treated rats exhibited no change in sexual behavior such as mounts and intromissions, ejaculatory behavior was completely abolished. The data suggest that this population of neurons may function as an ejaculation generator in the spinal cord.
Related Products: SSP-SAP (Cat. #IT-11)
Descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain.
Burgess SE, Gardell LR, Ossipov MH, Malan T, Vanderah TW, Lai J, Porreca F (2002) Descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain. IASP 2002 Abstracts International Association for the Study of Pain, San Diego, CA.
Related Products: Dermorphin-SAP / MOR-SAP (Cat. #IT-12)
Loss of IB4 staining in dorsal root ganglion neurons after spinal nerve ligation is not the result of cell death.
Arunkumar R, Ackerman LL, Jones III R, Holdsworth R, Proudfit HK, Hammond DL (2002) Loss of IB4 staining in dorsal root ganglion neurons after spinal nerve ligation is not the result of cell death. IASP 2002 Abstracts International Association for the Study of Pain, San Diego, CA.
Related Products: IB4-SAP (Cat. #IT-10)
Memory consolidation and the amygdala: A systems perspective
McGaugh JL (2002) Memory consolidation and the amygdala: A systems perspective. Trends Neurosci 25(9):456-461. doi: 10.1016/s0166-2236(02)02211-7
Objective: To investigate the involvement of basolateral region of the amygdala (BLA) projections.
Summary: The BLA acts via projections to brain regions involved in forming and consolidating memories of different kinds of experiences.
Usage: Lesions of nucleus basalis magnocellularis (NBM) induced by infusions of 192 IgG-SAP block the memory enhancement (in a 48-hr retention test), as induced by post-training infusions of noradrenaline administered into the basolateral amygdala immediately after inhibitory avoidance training.
Related Products: 192-IgG-SAP (Cat. #IT-01)
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Loss of IB4-positive sensory neurons mitigates the consequences of nerve injury in the rat.
Tarpley JW, MacIntyre E, Martin WJ (2002) Loss of IB4-positive sensory neurons mitigates the consequences of nerve injury in the rat. IASP 2002 Abstracts International Association for the Study of Pain, San Diego, CA.
Related Products: IB4-SAP (Cat. #IT-10)
Role of lamina I neurons expressing the substance P receptor in the prevention and treatment of a spontaneous pain-like behavior following excitotoxic spinal cord injury (SCI).
Yezierski RP, Yu C, Lappi DA, Mantyh PW, Wiley RG (2002) Role of lamina I neurons expressing the substance P receptor in the prevention and treatment of a spontaneous pain-like behavior following excitotoxic spinal cord injury (SCI). IASP 2002 Abstracts International Association for the Study of Pain, San Diego, CA.
Related Products: SSP-SAP (Cat. #IT-11)
Plasticity of wide dynamic range neurones following site-selective ablation of NK-1 receptor expressing lamina I neurones in rat spinal cord.
Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH (2002) Plasticity of wide dynamic range neurones following site-selective ablation of NK-1 receptor expressing lamina I neurones in rat spinal cord. IASP 2002 Abstracts International Association for the Study of Pain, San Diego, CA.
Related Products: SP-SAP (Cat. #IT-07)
Differential contribution of the cholinergic basal nuclei to attention and spatial memory in the rat
Lehmann O, Grottick AJ, Cassel JC, Higgins GA (2002) Differential contribution of the cholinergic basal nuclei to attention and spatial memory in the rat. FENS 2002 Abstracts 008.13. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Nicotine compensates for the loss of cholinergic function to enhance long-term potentiation induction
Yamazaki Y, Hamaue N, Sumikawa K (2002) Nicotine compensates for the loss of cholinergic function to enhance long-term potentiation induction. Brain Res 946(1):148-152. doi: 10.1016/s0006-8993(02)02935-9 PMID: 12133604
Objective: Investigate the mechanisms of how cholinergic lesions impair the induction of long-term potentiation (LTP) and how nicotine can reverse the effects.
Summary: LTP in the hippocampal CA1 region is involved in learning and memory and its induction depends on the activation of N-methyl-D-aspartate receptors (NMDARs). Nicotine is shown to reverse memory deficits caused by lesioning of the cholinergic system, but the mechanism for this observation is unknown. The authors use 192-IgG-SAP to induce cholinergic lesioning, which impairs LTP induction. The authors suggest the compensatory action of nicotine is a via enhancement of NMDAR responses mediated by nicotine-induced disinhibition of pyramidal cells.
Usage: 2 ug of 192-IgG-Saporin (Cat. IT-01) were injected into the lateral ventricle of rats.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Effect of 192 IgG-saporin on circadian activity rhythms, expression of P75 neurotrophin receptors, calbindin-D28K, and light-induced Fos in the suprachiasmatic nucleus in rats.
Beaule C, Amir S (2002) Effect of 192 IgG-saporin on circadian activity rhythms, expression of P75 neurotrophin receptors, calbindin-D28K, and light-induced Fos in the suprachiasmatic nucleus in rats. Exp Neurol 176(2):377-389. doi: 10.1006/exnr.2002.7969
Summary: The authors used bilateral icv injections of 200 ng of 192-Saporin (Cat. #IT-01) to investigate the contribution of p75NTR-expressing neurons to the determination of a circadian rhythm. The data show that p75NTR-expressing neurons are not essential for this process.
Related Products: 192-IgG-SAP (Cat. #IT-01)