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Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer’s disease.
Hyde LA, Crnic LS (2002) Reactivity to object and spatial novelty is normal in older Ts65Dn mice that model Down syndrome and Alzheimer’s disease. Brain Res 945:26-30. doi: 10.1016/s0006-8993(02)02500-3 PMID: 12113948
Summary: The authors hypothesized that a mouse model for Down syndrome may show some of the same cognitive deficits exhibited by rats lesioned with 192-Saporin (Cat. #IT-01), which eliminates cholinergic cells in the basal forebrain. The results suggest that in this Down syndrome model, cell loss has a much greater cognitive effect if it happens early in development as opposed to in adulthood.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors.
Simons CT, Gogineni AG, Iodi Carstens M, Carstens E (2002) Reduced aversion to oral capsaicin following neurotoxic destruction of superficial medullary neurons expressing NK-1 receptors. Brain Res 945:139-143. doi: 10.1016/s0006-8993(02)02913-x
Summary: Capsaicin-induced irritation of the dorsal anterior tongue is mediated by nociceptors expressing VR-1 receptors. The role of NK-1 receptor-expressing neurons during the ingestion of capsaicin was examined by injecting 20 µl of 2.27 µM SP-SAP (Cat. #IT-07) into the cisterna magna of rats. Lesioned rats consumed significantly more water containing high concentrations of capsaicin than control animals.
Related Products: SP-SAP (Cat. #IT-07)
Impairment and restoration of spatial abilities following 192 IgG-saporin or quisqualic acid lesions of the median septum in rats
Brandner C (2002) Impairment and restoration of spatial abilities following 192 IgG-saporin or quisqualic acid lesions of the median septum in rats. FENS 2002 Abstracts 210.3. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Short and long term-effects on the serotonergic system of a selective cholinergic lesion in rats.
Ramirez MJ, Garcia-Alloza M, Lasheras B (2002) Short and long term-effects on the serotonergic system of a selective cholinergic lesion in rats. FENS 2002 Abstracts 010.16. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Targeting serotonin re-uptake transporter (SERT) -expressing cells with a monoclonal antibody to an epitope from the extracellular domain of SERT: Results with a saporin conjugate.
Lappi D, Kohls M, Majer K, Russell B, Blakely R Richerson G (2002) Targeting serotonin re-uptake transporter (SERT) -expressing cells with a monoclonal antibody to an epitope from the extracellular domain of SERT: Results with a saporin conjugate. FENS 2002 Abstracts 049.7. Federation of European Neuroscience Societies, Paris, France. PMID: 0
Related Products: Antibody to Serotonin Transporter (SERT, Cat. #AB-N09), Anti-SERT-SAP (Cat. #IT-23)
Effects of mice EGF-responsive neural stem cells grafts and fetal septal cells grafts implanted into the dorsal hippocampus of rats after immunotoxic denervation
Jeltsch H, Aloy E, Schimchowitsch S, Caillard S, Mohier E Cassel JC (2002) Effects of mice EGF-responsive neural stem cells grafts and fetal septal cells grafts implanted into the dorsal hippocampus of rats after immunotoxic denervation. FENS 2002 Abstracts 141.13. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Selective lesioning of the developing cholinergic and noradrenergic systems: Anatomical, neurochemical and functional effects
Leanza G, Cataudella T (2002) Selective lesioning of the developing cholinergic and noradrenergic systems: Anatomical, neurochemical and functional effects. FENS 2002 Abstracts 151.12. Federation of European Neuroscience Societies, Paris, France.
Related Products: Anti-DBH-SAP (Cat. #IT-03)
Selective neonatal lesions of the basal forebrain cholinergic neurons impair memory of socially-transmitted food preferences in adult rats
Ricceri L, Moles A, Scattoni ML, Calamandrei G (2002) Selective neonatal lesions of the basal forebrain cholinergic neurons impair memory of socially-transmitted food preferences in adult rats. FENS 2002 Abstracts 209.4. Federation of European Neuroscience Societies, Paris, France.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm.
Johnson DA, Zambon NJ, Gibbs RB (2002) Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm. Brain Res 943(1):132-141. doi: 10.1016/s0006-8993(02)02623-9
Summary: The authors investigated the effects of selective cholinergic depletion in the medial septum on a spatial memory (DMP) task. Direct infusion of 0.22 or 1.0 µg 192-Saporin (Cat. #IT-01) produced a near complete depletion of cholinesterase-positive neurons for either dose. The DMP task provides a sensitive behavioral assay for deficits in cholinergic projections.
Related Products: 192-IgG-SAP (Cat. #IT-01)
Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain: A neurochemical and behavioral study.
Lehmann O, Jeltsch H, Lazarus C, Tritschler L, Bertrand F, Cassel JC (2002) Combined 192 IgG-saporin and 5,7-dihydroxytryptamine lesions in the male rat brain: A neurochemical and behavioral study. Pharmacol Biochem Behav 72(4):899-912. doi: 10.1016/s0091-3057(02)00752-9
Summary: Female rats treated with both 192-Saporin (Cat #IT-01) and 5,7-DHT exhibited working memory impairments that were not seen with either treatment alone. For this paper, male rats were treated with 5,7-DHT and 1 µg per ventricle of 192-Saporin. While each compound produced a unique combination of effects, cognitive performance was only affected by treatment with both agents. These data indicate that interaction between the cholinergic and serotonergic mechanisms plays a role in cognitive functions for both sexes.
Usage: Injections of 1 µg per ventricle of 192-Saporin (Cat. #IT-01).
Related Products: 192-IgG-SAP (Cat. #IT-01)